Vitamin D and Anemia: Insights into an Emerging Association

[WideBody]

Found an interesting study. The conclusion sold it for me.

ncbi.nlm.nih.gov/pmc/articl...

CONCLUSION

Vitamin D is associated with anemia in various study populations and recent evidence suggests that the association may differ by race and is likely specific to anemia of inflammation. The link to anemia of inflammation is supported by recent investigations showing that vitamin D can reduce hepcidin-stimulatory proinflammatory cytokines, thereby reducing hepcidin, and act on hepcidin directly by downregulating HAMP mRNA transcription. Recent studies have also suggested that vitamin D may support erythropoiesis, possibly through reduction of proinflammatory cytokines and increased erythroid progenitor cell proliferation. Other factors on the bone-mineral axis, including FGF-23 and PTH, may have regulatory roles in iron homeostasis and erythropoiesis, and there is some evidence suggesting that the actions of FGF-23 may be independent of vitamin D [25&&]. The interplay between all three hormones in regulating iron metabolism will be an interesting area of future study.

In summary, there is strong evidence both epidemiologically and mechanistically to support a role for vitamin D in iron metabolism, but further clinical trials are needed to clarify the therapeutic efficacy of vitamin D in improving anemia.

[wanttosleep]

You might find this article interesting also. It is specifically about vitamin D and RLS. Published on 6 Apr 2023.

tremorjournal.org/articles/...

[DicCarlson in reply to wanttosleep]

VERY informative article - and from a fascinating journal "Tremor" . This could be of interest to many... "Diker [109] reported significant clinical improvement of dopaminergic augmentation experienced by an 81-year-old female by slow tapering off of offending agents, cotreatment of iron-deficient anemia, and vitamin D supplementation. Symptoms were fully resolved after eight weeks of D3 supplementation (50,000 IU/week). Symptom-free maintenance was achieved by replacing pramipexole with gabapentin first, then pregabalin (150 mg/day), iron capsules, and 400 IU/day of oral vitamin D."

[WideBody in reply to wanttosleep]

Wonderful article, thank you so much. It's gonna take me awhile to digest this one but it does look very promising. I think my RLS benefited from large doses of Vitamin D.

[Graham3196 in reply to WideBody]

how large is your Vitamin D doses?

[WideBody in reply to Graham3196]

Way back when my doctor told me to take 4000IU, I was already taking 4000IU a day, so I jumped to 10,000IU a day. I know take between 10,000and 20,000 IU a day. I also test every 4-6 months.

[Jumpey]

Cheers.Thanks for posting.

[Merny5]

Thanks for sharing this. My primary doctor just increased my vitamin D dose from 50,000 units weekly to 100, 000. I will have to pay attention and see if this makes a difference with my symptoms. Wouldn’t that be wonderful for all of us!