Lactobacillus reuteri , Mucuna Pruriens , and magnesium malate to treat RLS

[Little_apple]

Hello, Newbie to the forum wondering if Mucuna Pruriens is used by people on this forum?

Magnesium Malate , which helps the iron cross the BBB?

And Lactobacillus Reuteri? (Recommended for RLS by Dr. Will Davis)

[Madlegs1]

I can assure you that everything and anything possible in this galaxy, has been tried to relieve RlS.

Each person reacts differently, so , very often it's a question of trial and error, and reporting back here with the results!💚💚💚

Mucuna has been tried , with mixed results.

Microbiome in the gut seems to be quite important-- as is the whole diet thing.

Magnesium, in general ,is good, but I haven't come across that particular concept. Certainly worth trying.

Please let us know how you get on.

And Good luck.

[SueJohnson]

Lactobacillus Reuteri a probiotic helps people if they have SIBO or IBS. Which in turn helps RLS. I don't believe it helps RLS if you don't have those conditions.

[Little_apple in reply to SueJohnson]

you mentioned Azilect as not being documented as a med that augments RLS. But levodopa is because it increases dopamine. Azilect increases dopamine. Unfortunately my theory that Azilect has worsened or brought on my RLS is not looking to be too far fetched. I don’t know what to do now. Both PD and RLS…I’m feeling rather doomed.

[SueJohnson in reply to Little_apple]

But they act in different ways. Opioids also increase dopamine and except for tramadol do not cause augmentation.

[ChrisColumbus]

Welcome! If you hit 'Posts' below the 'Write' button near the top of the screen a search box will open and you can enter your keyword and find all posts on this forum which mention that keyword.

You'll find Mucuna mentioned, with some suggestions that it helps at first but then makes things worse, referencing augmentation.

Lactobacillus and probiotics in general are mentioned as being good for (gut) health generally.

Magnesium malate is mentioned, but more commonly Mg glycinate and Mg citrate. I found that citrate worked for me, but it can have a laxative effect; glycinate apparently doesn't have a laxative effect and is said to help sleep.

Magnesium definitely helps some (including me) but not others (including my brother).

The supplement that most commonly helps RLS sufferers is iron. If you have a full iron panel blood test - after fasting overnight, and after ceasing any iron supplements for 48 hours - you are looking for your serum ferritin to be over 100 - preferably higher - and your transferrin saturation to be between 20 and 45. If your Ferritin is lower than this, oral iron supplementation is advised and over time helps the majority with their RLS.

NOTE: if you take both iron and magnesium take them 2 hours apart.

[ChrisColumbus]

Further to the above: I had RLS regularly for decades - my mother had it, as do two of my siblings. I've never taken drugs for RLS, just put up with it.

My iron levels have never been low. I only started to get on top of RLS when I discovered magnesium citrate: previously I'd tried magnesium oxide (a waste of time) and magnesium oil (didn't work). Magnesium citrate initially stopped my RLS within days.

I then discovered things that would give me RLS despite the magnesium: statins; too much sugar; artificially sweetened diet food and drinks - particularly aspartame; too much caffeine; too little exercise; too much exercise; lying on my back too much...

Now generally avoiding the above, I've finally been RLS free every night for the last month.

[Little_apple in reply to ChrisColumbus]

RLS free for a month! 😍 music to my ears. Congratulations!

Magnesium Malate is a form that enables iron to get in to the brain. Having it in the blood does not mean the brain is receiving what it needs. See recuced iron metabolism for that. )If I’m preaching to the choir here, please forgive me. I’m new and I might be stating the obvious or asking basic questions. )

[ChrisColumbus in reply to Little_apple]

Serum ferritin levels are currently generally regarded as the best guide we have to brain iron stores.

Interestingly, I can't say that I've seen that suggestion about Mg malate, here or elsewhere, and can't find a reference to it on a quick search. Do you have a source?

[Little_apple in reply to ChrisColumbus]

I do. I have it on the PD forum. It’s from Harvard I think

I will seek it out and post it.

It’s about iron metabolism

[ChrisColumbus in reply to Little_apple]

Had a quick look on the Cure Parkinsons forum and saw your post about Lactobacillus plantarum 299 being especially efficient at breaking down iron so that can cross the BBB....

I think your source on magnesium malate would be of general interest here and deserve a Post of its own.

[Little_apple in reply to ChrisColumbus]

I will accumulate more information and write a post in the near future. Thank you for your interest and support.

[Little_apple in reply to ChrisColumbus]

commenting against to say “thank you.” Learning of your improvements via addressing your SIBO has given me hope and hope is priceless!

[DicCarlson]

When I started with RLS - I took Mg in the form of Malate (Jigsaw Health). Mostly I had a paradoxical reaction - excitable rather than relaxing. After a time I discovered the iron connection (ferritin 49) and resolved severe RLS with iron supplements. I also had a lot of leg cramps and ramped up dietary Mg - pumpkin seeds, potatoes, etc. Also took commercial electrolyte solutions. Today I take Magnesium L-Threonate. It is also called brain Magnesium - and is a patented formula called Magtein. Any brand will work - here is their website - look at the FAQs.

magtein.com/