Has anyone tried NAC N-acetylcysteine? Did it help? I accidentally found this, my first thought was how could they miss this?
"Glutamate can be reduced in the brains of persons with high glutamate levels within an hour of oral ingestion of N-acetylcysteine"
I am taking it at the wrong time!
If your interested, I found it here: examine.com/supplements/n-a...
Following
I can see how it could help some people if their RLS is due to inflammation caused by chronic oxidative stress caused by foods such as refined seed oils which are mostly PUFAS (polyunsaturated fatty acids) as it is an anti-oxidant.
In my books there is no such thing as primary RLS, it all has a cause, you just need to search for it.
I took NAC a couple of different times to try and assuage Glutamate (excitable) in favor of GABA (relaxing). I used NAC Sustain from Jarrow (600mg, timed release). I can't say it did much if anything. From holistic help...
"N-acetylcysteine (NAC) is supposed to be a glutamate scavenger and may be suggested to increase GABA, however, it also increases glutathione, and excess glutathione can increase glutamate, so this may or may not provide relief."
holistichelp.net/blog/how-t...
thank you
Eating habits are usually learned behaviour from parents, that's why conditions are often thought of as genetic. I was the same before I learned of the damage done by eating habits. A pity that I hadn't learned about them before my father's death because I might have saved him.
That's true in some instances but in respect to nutrition, what's also very pertinent is that one's parents nutritional status (both preconception and in utero) can contribute to the health of an individual over their life course.
Even more interesting is that, in respect to particular health conditions, the health/nutritional status of one's grandparents has a bigger influence over outcomes than one's parents.
And eating habits doesn't adequately explain why, in the case of identical twins raised in the same household, one develops RLS and the other doesn't.
While genetics 'loads the gun' it's often that eating habits 'pulls the trigger', and people develop different conditions on the same diet, for instance some will develop cardiovascular disease first while others get obeese first or others might get neurological problems first. Eventually people will get a number of conditions although one may be the most noticeable.
I remember first noticing it after a trip to a fairground when I was seven. I had eaten lots of sweets whilst there but didn't make the connection at the time.
Thank you for posting. I will give it a try.
You must be from across the pond. 50 years ago, hmm, Wonderbread, TV dinners, jiffy pop and twinkies. 
We had junk food 50 years ago.
We used to look with wonder and envy at these products on imported TV programmes!
Interesting question about the effect of Nac on rls WideBody!
A friend of mine started this "forgotten" medicine a few months ago for a lung disease (pulmonary fibrosis) with truly amazing results!!! It is a strong antioxidant and has a positive effects on many complaints.
In the report you referred to, a positive effect was found on glutamate and dopamine levels and that could be positive for our RLS. NAC is easily to buy in 600 mg capsules. DicCarlson wrote he didn't have much of a result. But although I want to try 600mg a day. Perhaps the right dose is important. (Less = more). See the passage below:
"N-acetyl cysteine (NAC) is a powerful antioxidant with numerous health benefits. For years it has been used in various conditions such as depression, bipolar disorder, OCD (Obsessive-Compulsive Disorder), PTSD (Posot Traumatic Stress Disorder), schizophrenia, eating disorders, Alzheimer's disease, Parkinson's disease, sleep problems, infections and inflammation"
"Glutamate may be reduced in the brains of individuals with high glutamate levels within an hour of oral intake of N-acetylcysteine (NAC)"
Dopaminergic Neurotransmission
The release of vesicular dopamine from neurons appears to be enhanced in the presence of N-acetylcysteine at low concentrations, but very high concentrations (10 mM) tend to inhibit its release, which may be related to how glutathione interacts with the neurons. glutamate-evoked dopamine release."
Who has more experience or information about NAC and the influence on rls?
Is it safe to try?
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