I know it is rather a controversial, not to say hugely divisive, subject for such a friendly forum and is probably on a par with soap-in-the-bed in terms of usefulness but my meds are kicking in and my inhibitions are lowered. I was prompted to look at research about Marmite after hearing unverified anecdotal accounts of a positive response by an alzheimer sufferer to a marmite inclusive diet (ok I heard it from my mother who is now force-feeding the stuff to my recently diagnosed father). Anyway, it turns out that in a randomised controlled very small study marmite had a positive impact on the concentration levels of a group of adults in their twenties. As I understand it (although not only am I not a scientist but I have the ability to retain scientific information commensurate with that of marmite to satisfy someone who is looking for something very sweet and not at all salty), the Marmite, which is packed with vit B 3, 6 and 12, increases the production of gaba in the brain. The gaba sort of tamps down the buzzy effect of its alter-ego glutamate and this means the consumer of the marmite is more focused.
The relevance of this for an RLS forum is: I read somewhere that, when tested, RLS sufferers were found to have higher levels of glutamate and there is a suspicion that Glutamate receptors may have some role in the condition. Also the insomnia dimension of rls could be connected with the over-production of glutamate and/or the under-production of gaba SO maybe we should all be eating Marmite, notwithstanding that, as someone posted in a 'how-to-eat-marmite' forum, it smells like all the sadness of the world packaged in a jar - it sort of looks like that too to me.