I thought I would post some info on glutamate/glutamine and its (supposed to happen) conversion to GABA (which is problematic in RLS people.) Glutamate is excitatory and GABA is inhibitory. Glutamate is what keeps one awake and stimulated, while GABA is what helps one relax and sleep. These are some of the most important issues to understand. RLS people, ( as well as others with Parkinson's, Huntington's, Autism, etc, etc.) are often lacking the GAD enzyme to make the conversion from glutamate to GABA in their bodies . This is why understanding this is important, no matter how you go about treating it.
A very good explanation is to be found at;
holistichelp.net /blog/how-to-increase-gaba-and-balance-glutamate/
It was an eye-opener for me, in many ways. So, I suggest reading it, and perhaps pursuing some of the lines of thought brought up.