Probiotic to increase GABA and reduce... - Restless Legs Syn...

Restless Legs Syndrome

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Probiotic to increase GABA and reduce glutamate

8 Replies

For those of you who are interested in the GABA / glutamate balance and its contribution to RLS / PLMD, here is an article that discusses the use of a probiotic to increase GABA and reduce glutamate.

pubmed.ncbi.nlm.nih.gov/295...

(I'm unable to access the full text article).

The study indicates that probiotics can be used safely to ameliorate glutamate excitotoxicity mostly through increasing depleted GABA and Mg2+ and decreasing the excitatory neurotransmitter, glutamate.

Read more about...
8 Replies
Joolsg profile image
Joolsg

Thanks Amrob.The gut is the second brain!

I always recommend a good probiotic.

SueJohnson profile image
SueJohnson

Interestingly gabapentin reduces glutamate levels in the brain.

in reply toSueJohnson

Yes, there seems to be a few medications that reduce glutamate levels, especially the anticonvulsants. As always, i'm looking for that unicorn...a non-pharmaceutical solution!

RCHD profile image
RCHD

Here’s a free article :

ncbi.nlm.nih.gov/pmc/articl...

in reply toRCHD

Thanks for this RCHD. It seems that the strain bifidobacterium adolescentis IPLA60004 is a useful one in reducing glutamate concentrations in the blood. Now to find it in a probiotic preparation...

RCHD profile image
RCHD in reply to

Yes good point! I was overzealous to send.. sorry it wasn’t exact same. But it’s good to see people are paying more attention to the gut brain relationship. Thanks for bringing it to my attention.

in reply toRCHD

It was the paper that you linked that gave me the name of the strain, so thank you. Yes, the more i read, the more research i see going in the direction of gut microbiota regulation for a vast range of conditions. All very encouraging.

RCHD profile image
RCHD in reply to

Yes it definitely is! It’s exciting to see and pray it can help to lead to a cure one day !! Thank you too !

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