Hi Nightdancer. I hope you are still on this site. I have a sensation of internal vibrations. It started with simply a couple of nerves "jumping" in my feet. About 6 months ago the internal vibration feeling started in my left foot, then moved to my right foot and then one night the vibrations rapidly moved up my body to just under my breasts. The internal vibrations continue. I've had a Nerve Conduction study and they found a little weakness in my lower legs. I've been on Gabapentin, started at 1 pill 3 times a day until I was up to 3 pills 3 times a day. They have not been much help, not to mention I'm so tired from them. This week my GP put me on Neupro. Within 3 hours of placing the patch, my back started itching, then my breathing became very labored. I have an Epipen and had my Grandson run for it, by the time he got it back to me , I had ripped off the patch. Within a couple of minutes, Without the Epipen, the itching stopped and I could breathe again. My face was red and I felt weak and not quite myself. I took my BP (thinking it was either low or high) and it was normal. I have COPD, am allergic (anaphylaxis) to Penicillin, all Moxifloxacins and Morphine. I have reactions but not anaphylaxis to Bactrim and Keflex. I have a Dr. appt next Thursday but ran across this site so I wanted to know if anyone else has experienced the same reaction to Neupro as I did. Is there something safer for RLS if indeed that's what I have. I only have the extremely annoying internal vibrations and nerves jumping in my feet. I don't have burning or pins and needles sensations.