Statins have been mentioned on here before but the following statement from a member 11 months ago is worth repeating here:
"Yes, I have a cholesterol problem but cannot touch any of the meds available. My RLS immediately worsens if I do. Have tried several of them. Fortunately my HDL/LDL relation is very favourable so I need not worry too much about it. All I can suggest is that you lower (or at least try to) your cholesterol levels with the correct diet. I found that the juice of half a lemon in a glass of water first thing in the morning helps a lot. It has MANY other health advantages too. I have my RLS under control (am awake for at the most 15 minutes per night) by taking four Arginine (L-arginine) (I prefer the Solal product) after breakfast. It takes a month or two of regular use before you will notice the difference. L-Arginine apparently boosts your blood flow to the legs, calming them. Hope this helps."
The vast majority of the people on this earth can take statins and never experience RLS. For those of us pre-disposed to RLS, statins can possibly trigger or make RLS much worse than it needs to be. Statins inhibit iron. Our poor brains have so little iron to begin with then add an iron reducing drug and you have sheer madness.