When I was first diagnosed with rls, the first med i was given was requip... which i wasn't able to take because it made me vomit. After that, the doctor gave me tramadol and it was like a miracle. I was finally able to sit at my desk at work during the day, watch tv on the couch in the evening, and fall asleep in bed at night. It only last a few months, though. It still took the edge off enough to fall asleep at night, but I wasn't getting the daytime relief anymore. And to make matters worse, the tramadol was giving me sleep apnea, so I was excessively sleepy during the day and would have sleep attacks on even short drives. The sleep apnea and sleep attacks went away once I stopped using tramadol. The doctor switched me to the neupro patch (starting at 1 mg up 4 mg), but i didn't get any relief from it (plus it was giving me headaches and weight gain). After the patch, i was put on horizant. Again, no relief. I put myself on 600 mg of neurontin at bedtime just to be able to sleep at night. Now the doctor has me on .25 mg of mirepex for 5 days, moving up to .5 mg for five days after that. So far still not getting any daytime relief from it, but i have been able to sleep at night at least. However, I've heard there can be some scary side effects from mirapex (it's already giving me headaches), though. And since I'm not getting any appreciable results better than what I was getting with neurontin, I'm thinking about asking the doctor if i can just switch back to it. RLS is so frustrating. From what I've read, there's really nothing that will make it go away. Even if we're lucky enough to find a med that relieves our symptoms, it seems it doesn't last long before that med stops being effective. I didn't really want to switch to mirepex, but the doctor told me it would help me sleep better at night - and that if i slept better at night, i'd feel better during the day and in the evening. So far that hasn't been the case. I suspect my type of rls is only relieved through the pain meds, but i can't take vicodin without vomiting and i can't take tramadol without getting sleep apnea (not to mention the fact that it completely kills my libido). So i don't know where to go from here. Anyway, thanks for letting me get that off my chest.