Drug reduces Tau

This just posted by CurePSP "In addition to developing new compounds, Brannelly said the group is open to other approaches. Among the four treatments being tested on PSP patients are a blood transfusion therapy and a generic drug that has been used primarily for arthritis. Also, an antibody created by consortium researchers and licensed by Abbvie is moving into Phase Two clinical trials on patients with PSP and early Alzheimer’s disease, the pharmaceutical company said this week."

Another half-dozen compounds are in the pipeline and headed toward testing. One potential treatment has recently shown promising results in animals, according to an article published this week in the journal Science Translational Medicine. Researchers tested a compound with a synthetic molecule, known as an antisense oligonucleotide, on mice and monkeys and found that it reduced tau in the brain and the Alzheimer-type damage it can cause.

Dr. Tim Miller, a professor of neurology at Washington University in St. Louis who was a senior author on the article, said similar compounds have been approved for neuromuscular diseases and are being tested in human trials for some neurological diseases. Human clinical trials on PSP patients are expected to begin later this year.

“The fact that this kind of compound is in human clinical trials is reason to be optimistic,” he said."

Read more here: star-telegram.com/news/loca... neurology-central.com/2017/...

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5 Replies

  • Thanks, Christine! Very interesting and encouraging. The cure will be too late for many of us, but I'm happy to know that it is coming. I believe!

  • I am sure, once they find a way to stop the Tau attacking the neurons, PSP sufferers should be able to make a substantial recovery. After all there was never anything wrong with the mind or body. Fingers crossed for everyone out there.

    Lots of love


  • This is very encouraging news. It's great to know that this research is being carried out. I wonder if there is much exchange of information between researchers in various countries to help push things along. Hope so.

  • Thanks Christine.

    A heartening read.

  • Lots of new info the past few days. Let's hope there's more to come 👍

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