Unusual results

[Stephen399b]

I have PC (originally Gleason 4+3 and PSA of 10) which has metasticised to a number of bones - pelvis, ribs, skull. I am taking Aberaterone and Prednisol, plus Prostap.

My recent PSA scores have been >0.1 (undetectable), but I have just had my third PSMA PET scan which shows that the activity in some of the the metasticised areas is increasing. This seems counter intuitive if the ADT medication has reduced the cancer activity?

Welcome any thoughts?

Stephen

[Hidden]

I think you mean <.1. Uptake seems unlikely to represent growing cancer to me. In rare instances PSA can be absent while cancer grows, though. What does your radiation incologist or MO say? Specifically what does it say under “IMPRESSION ?” This should also be posted under the Advanced Prostate Cancer section. Probably get more input.

[Stephen399b]

Thank you for this.

I have also been looking at FenBenz as one of our friends who has a different cancer is taking it.

Has anyone else any experience or knowledge.

I am very wary of 'off piste' medication, but this certainly seems to have some traction?

Stephen

[cpcohen]

>>> . . .In rare instances PSA can be absent while cancer grows, though.

>>>

I missed a lecture at my local support group, last year.

The gist of it, was that in advanced PCa, after several different treatments have failed, low-PSA cancer isn't "rare", but fairly common. I think the number mentioned was 10%-15%.

As they mutate, the tumor cells behave less and less like normal prostate cells, whose main purpose is to generate PSA.

. Charles

[Hidden in reply to cpcohen]

Recent discussions appears you are right. I have a slide in a Dr. Kwon presentation that says 12% of his patients. Of course he is going to have serious cases. But how long before that begins? The OP has only been on first line hormone therapy 10 months or so.

[cpcohen in reply to Hidden]

You're right. But if PSA is steady, and there's more metastatic tumor growth, you have a choice of diagnoses:

(a) the PSA is misleading -- the tumors are prostate cancer, but aren't producing PSA;

(b) the PSA is right -- the scan is wrong, or the tumors aren't prostate cancer, but something else.

I don't know what the stats are. This is a puzzling situation, out of my bailiwick.

. Charles