Hello Everyone, I am wondering if anyone has any information or experiences with neurontin and the inflammation we are dealing with in GCA and PMR?
trying to do as much of the anti inflammatory daily living -- in dealing with this.
I found this on a site which seems ok. Doctors are responding to questions and their information is available. On our web pages, they usually separate sites that are trying to sell a product and sites that really deal with an issue. This site is not part of the sites, labelled "Advertisement". Would say of course, talk with doctors and do your own research, but this is what I have come up with --
I have not found an exact response to "what is the effect of neurontin on inflammed arteries"
Found this, which may be helpful on a site, by Gaye and Andrew Sandler. It seems Gaye uses neurontin and has been asked by Pfizer to do some further research on it. She gives information, no pressuring to use it. Her information seems helpful. and again, a doctor, or practioners are the best. I bring this kind of information to my doctors and usually we come up with a "plan".
Here, she is saying that it stops the production of a substance that causes inflammation and this, I believe, is the end result we are working towards. So, my perception, is that it may help.
" . . . Neurontin helps to stabilize misfiring nerves by slowing down neurological impulses traveling from the spinal cord out to the peripheral tissues. There is the probability that Neurontin decreases Substance P activity. Substance P is a neurotransmitter chemical in the pain system that carries pain messages through the nerves and stimulates inflammation. Elevated levels of substance P have been found in IC and FMS patients.
It is believed that Neurontin reduces the over-stimulation of nerve endings in IC patients. According to Dr. Seastrunk, a psychiatrist in Texas, "Neurontin also appears to minimize a focal brain injury in Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FMS) patients."
Presumably, part of the brain's limbic system, the hippocampus may be damaged by stress chemicals (such as adrenaline and cortisol) in CFS and FMS patients. The hippocampus is responsible for controlling the stress response network. It also handles pain signals, routing them from the spinal cord to the brain. The nervous system in CFS and FMS patients is thought to be in a state of hyper-stress. Exposure to stress chemicals may cause the development of chronic pain, as well as, memory and learning problems in these patients. The actions of Neurontin seem to minimize the sympathetic pain. ..."
Another valid site:
In response to "What does neurontin actually do?" , from Doctor Ronald Krauser
The exact mechanism is not fully understood. Neurontin may work by binding to certain sites on nerve cells in order to block the release of glutamate. Glutamate in turn causes nerve cells to be abnormally excited and therefore accentuate pain. "
From Doctor Norman J. Marcus
"There are many reasons for hand pain. If there is suspected nerve problems causing the pain, Neurontin may help. Swelling will not be helped and Neurontin can actually cause swelling in the hands, legs and feet in some people."
From Doctor Bennett Machianac
"Neurontin: drowsiness, dizziness, weight gain, ankle/foot edema. Elavil: visual blurring, mouth dryness, difficulty starting urination, drowsiness, dizziness, weight gain, lethargy, paradoxical anxiety, and maybe forgetfulness."
From Doctor Brian Le
"Neurontin is not an anti-inflammatory medication. It is anti-seizure medication. it is effective for nerve pain, like sciatica."
Neurontin is working well for me with neuropathy and migraines.
Believe the question is -- what effect does it have on the arteries. Can it cause or increase swelling?
If anyone has information or experience, would you share ? Thanks. best, Whittlesey