I had a biopsy done in December 2011 which radiologist stated was a form of hepatitis. I then had that same biopsy sent to Johns Hopkins and they stated because I have had a positive AMA that it is PBC but biopsy showed could be a form of hepatitis. My AMA was positive one time, negative 1 time and very very slight the 3rd time. So my question is what exactly do I have? I'm being treated for PBC (urso 3x's a day)...could I have an overlap. I just want to make sure I should not be being treated for autoimmune hep also. My Hep panels were negative and I was neg for ANA. My ALT & AST numbers are back within normal range but my alka phos is still in the 200's. Just curious what you guys think.