'Thank you' researchers!: medicine.washu.edu... - PBC Foundation
'Thank you' researchers!
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DonnaBoll
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very, very interesting. Thanks for sharing.
Washington University is about an hour from my house. Huge research and hospital facility.
Great news for those with SAVI and potentially other autoimmune diseases as well. The ArfGAP2 protein appears to play a major role in regulating STING, another protein that regulates cytokine and chemokine secretion, immune cell activation, and autoinflammatory pathology. Knocking out ArfGAP2 (in mice) reduces these effects by STING and is perhaps a promising target for autoimmune therapy.
From Poddar et al. (2025) https://doi.org/10.1016/j.cell.2025.01.027
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