NRH on biopsy

[Artsy123]

has anyone with findings on their biopsy with Nodular regenerative hyperplasia? I hope I spelt it right…. If anyone can tell me what happens after it is found ( tests. Monitoring)I’d be grateful. Thank you!

[DonnaBoll Administrator]

I can imagine how concerned you must be getting all these strange words thrown at you. It's easy to just google these findings, but I really suggest that you make an appointment/or send a message to the doctor who did the biopsy. He needs to answer all of your questions. Wish I could be more helpful but not knowing any of your history, best you talk with the doctor.

[Artsy123 in reply to DonnaBoll]

Thank you Donna…. Two years ago my gastroenterologist who had the liver biopsy done mentioned I had PBC. I then saw a rheumatologist who diagnosed secondary sjorgrens. I had very few answers to anything with regards the pbc so I requested to see a hepatologist clinic . At the clinic they were so thorough with testing but the consult note mentioned the NRH from the original biopsy. I have sent a message to them to get more information. Likely they may have assumed I was already made aware from the GI doctor but I had not been. I’ve read a lot on it but just wondered if anyone had personal stories. As far as I know I have no symptoms.

[NotorDJP]

This is what Dr. Google said. Nodular regenerative hyperplasia (NRH) is a benign condition characterized by the formation of small, non-cancerous nodules in the liver.

[Fibro2021 in reply to NotorDJP]

While NRH (nodular regenerative hyperplasia) is often described as ‘benign’ because it is not cancerous, it is not necessarily harmless. NRH can lead to significant complications, particularly portal hypertension, which may cause variceal bleeding, ascites, and even hepatic encephalopathy. Since NRH often goes undiagnosed for a long time, some patients first present with neurological symptoms due to hyperammonemia.

It is also frequently associated with systemic diseases or medications, making it important to identify the underlying cause. Calling it simply a ‘benign condition’ without considering its potential consequences might be misleading. Have you come across any studies or cases that describe NRH as entirely harmless?