Rogue Molecules that Trigger Autoimmunity

[EileenUSA]

I follow research on AI disease in general because while PBC is rare AI, diseases like MS and Lupus have so many more patients (2.3Million, 5M) lots of research is going on that COULD also be the key to stopping the trigger that causes PBC response.

And because of fast evolving technology in computing and laser tech etc.. researchers can get to results faster. Here is an example breakthrough -wehi.edu.au/news/dna-gets-a...

Some takeaways snipped from the article:

Quote:

"A research team has discovered the process – and filmed the actual moment – that can change the body’s response to a dying cell. Importantly – what they call the ‘Great Escape’ moment may one day prove to be the crucial trigger for autoimmune diseases like arthritis.

The research team discovered – and filmed – the exact moment when DNA escapes out of the mitochondria during cell death.

Mitochondria – the cell machinery that produce energy – are the ultimate double agent; they are essential to keep cells alive but, when damaged, they can trigger the body’s own immune system with potentially devastating consequences. The DNA inside mitochondria (mtDNA) has many similarities with bacterial DNA, and the body reacts to its presence outside the mitochondria, or indeed outside the cell, as if under attack from invading pathogens. A similar failure to distinguish ‘self’ from ‘non-self’ underlies inflammatory and autoimmune diseases. " End Quote

Anyway-- the article is fascinating.. and it does give me hope that scientists will figure out an OFF switch for damaging AI trigger.

[Skypony]

Thank you for sharing this, very interesting!

[Hidden]

Thank you for posting, it’s new reasearch too that makes it interesting. Perhaps reasearchers in pbc will look at this and take it further to find the moment pbc is being triggered.