Converging themes in the pathophysiology and treatment of PBC

[Betonarme]

researchgate.net/publicatio...

[GrittyReads]

This looks fascinating. I have not read the article properly (others: follow the link at the bottom of the message). However, from a quick skim it sounds optimistic, with the suggestion that far more means of treating PBC should be in the pipeline, now that they know far more about what goes on in PBC, at the micro- and biochemical level, with interactions in the cells of the liver and biliary tubules.

Thanks.

[Karaliz]

So interesting, particularly as I stopped responding to Urso and am fortunate enough to be on OCA as part of the long term safety extension arm of the trial. The new frontier of treatment after 20 plus years!

Thanks so much for posting.

Cheers from Downunder

Karaliz

[butterflyEi]

Hi Betonarme

Thank you. So good to know research will help better understand the difficulties pof PBC.

[Betonarme]

Looks like Scientists no more scratching the surface but they've got deeper. As they came back they bring valuable information. After reading the article above I'm questioning the term "autoimmune" at least in the case of PBC. I once heard (or read) that whenever there is no apparent cause they labeled it "auto immune disease".

If I understood it correctly, PBC starts with epithelial Cell death in Bile ducts because they lose their protection mechanism against bile flowing in bile ducts. And, this is somehow triggered by the malfunctioning (mutated or switched off) Genes. This is Epigenetics! Human genome changes during the lifetime.

After the cells starts dying, the mess they left behind triggers the Immune cells and the course of unlucky events follows. Somehow...

[donna01]

Did any of you see the articles at the bottom of this link? As I have ready continuously, this is very possibly caused by leaky gut syndrome. I have been taking probiotics for the last year now Fascinating info! I'm telling you all; we must avoid gluten!

researchgate.net/publicatio...

"Probiotics and pH Balance in the Gut. While probiotics are typically associated with a healthy digestive system, they may help to maintain a good pH balance in the gut too. Probiotics are “good” bacteria that assist with processing food as well as protect the immune system near the intestines"

[Sachin1234]

I was thinking about going gluten free but recently I'm diagnosed with reactive hypoglycemia which can lead me into diabetes!