Hi everyone hope your all well. I was diagnosed with pbc two and half years ago after a period of severe fatigue . After initial shock I started on urso responded well . Stopped smoking ate a healthy diet etc I lost weight and continued working 40+ hours a week and quite honestly felt quite well apart from arthritis and fatigue but over last few months I've gained weight around my middle developed itching (I've never had before) joint pain worsening and feel generally low and unwell .... are these signs pbc is progressing and not so respondent to urso ??