I have been diagnosed with PBC about 3 years now and on this 6 monthly blood test my TSH is now 10. It was 4.5 in July. My T4 is normal. I was having a 6 month break off URSO to see if it affected my ALT and ALP as they were fairly borderline go starting it in the first place. They have worsened a bit and I'm waiting for my consultant appointment now. I assume this TSH means I have an under active thyroid. I understand that when you have PBC you are more likely to develop other autoimmune disorders. I am waiting to discuss this with my gp, but wondered if any of you may have experience of it? I expect I'll end up on thyroxine?! Thanks in advance.