Hello everyone! I have a preliminary diagnosis of Papillary Thyroid cancer and they are talking to me about having my entire thyroid removed along with treatments later. My big concern, aside from the cancer diagnosis, is how the thyroid meds will work with my PBC. I have been reading horror stories about fatigue, etc on the ThyCa survivors site and It scares me because I already have significant fatigue with my PBC. Does anyone on here take thyroid meds, or had their thyroid removed? How does it effect you with your PBC? Did your Alk phos go up when you started taking the meds?