Does anyone have any info around the timescales for elimination of b12 from the body after injection in someone with malabsorption. I have read about a 6 day half-life, but elsewhere people suggest it is 24/48 hours until it is eliminated? My GP won't do injections every other day until no further improvement as per NICE guidelines for those with neuro symptoms and I'd like to be able to give her the reason why this is necessary.
Time for injected b12 to be eliminated - Pernicious Anaemi...
Time for injected b12 to be eliminated
I would see another G.p.Or ask then to get advice from a neurologist .
No idea why doctors don't read or go by the NICE guidelines .
What has your doctor offered ?
Have you had a referral depending on what your symptoms are .?
I had 5 loading dose in November and was told I should have 3 monthly maintenance beyond that. My symptoms improved (fatigue, tingling, tinnitus etc) but returned after just less than a month (I had low folate at the time of loading, which I didn't know about and so not optimal conditions for loading - I'm now taking folic acid and levels are high again). I am also under the care of oncology (surgery for cancer which removed my terminal ileum, hence the B12d) and I spoke to them last week about it all. They sent an email to my GP asking her to follow the loading guidelines (re-loading on alternate days until no further improvement then monthly thereafter) and she has agreed to re-load BUT only with 5 doses then monthly thereafter. She says they can't offer more than 5 for loading because "that's what they've always done!". Obviously this an improvement on Plan A but not what oncology requested and not what the NICE guidelines state. I've had the neuro symptoms for over a year - with initial loading in Nov they improved but didn't disappear. So I don't really expect anything different this time around. She is referring me this week (but will the consultant be any more informed/sympathetic?!).