Increase volume of b12 injected - Pernicious Anaemi...

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Increase volume of b12 injected

Tch77 profile image

Is it safe to inject say 2ml in 1 go, so I dont have to increase the frequency of injections

20 Replies

I woujd imagine so.Depends on how well you retain it and use it.

No idea how the 1mg dose was calculated

Might not lower frequency though??

I feel that the more one injects in one go, the more you waste and pee away. You may also have stronger symptoms, if you were significantly deficient before the injection.

I split my weekly dose in half, and injected twice a week and feel like I’ve leveled out the roller coaster ride from when I was taking the full 1 ml (1000 mcg/ml) in one go.

If you have the break open ampoules, then you’re pretty much committed to injecting the whole thing.

What strength B12 is it?

Are you supplementing with folic acid and a daily multivitamin to maximize the benefit of the B12 you are currently injecting?

How do you split your dose.? The only way I can think of is f you have the mutliuse vial with the rubber sealed top in a similar way to which vaccines are shipped in. Or do you use a single use vial and draw 0.5ml into two syringes and put one in the fridge for use later?

I’ve got rubber stopper vials that are supposed to be for single use, but I only use half.

Taking up the dose in two syringes sounds feasible for ampoules

Never heard of or seen that type of product. I am in the UK and we use the snap off single use glass vials. So essentially it is the same thing just a different lid/package. If I may ask how long have you been splitting the dose like that for and I am glad it works for you.

Multidose vials are why we see some people going on about preservatives. Though, as you rightly imply, no multi-dose vials of hydroxocobalamin are licensed here in the UK.

(Similarly to why vaccines and other injectable substances in multidose vials might contain preservative.)

Yes I agree and thought so. I guess it depends on the preservatives used in the multi dose vials. The B12 Vials ones in question seem to be single dose as per quote "I’ve got rubber stopper vials that are supposed to be for single use, but I only use half" I have never heard or seen this type before. Do they even exist?

No - never heard of them. But they did exist, in 1994!:

pubmed.ncbi.nlm.nih.gov/783...

Maybe they still do some places?

That was a different era then I guess. At least I know now. The only way to get 2x 500ug doses from the single dose 1ml glass ampule here would be to draw into two syringes, immediately set one aside in the fridge and use the next day or later that same evening.

I’ve been splitting my dose for around 10 years. Half on Monday and half on Thursday.

If keeping the second half in a syringe, you also need to protect it from light (uv) exposure. The vials are dark glass and syringes are clear.

Right got it, so as yours is a rubber stopper, you can safely draw out half dose. whereas for the glass ampules you are kinda taking a risk by keeping it in the syringe for later use as the B12 solution has already technically been exposed to the atmosphere.

Hi Tch77,

Safety wise - b12 is water soluble so excreted out. At one point I was having to inject 1 ml in a.m. and 1 ml in afternoon- I like to be able to feel and use my legs.

Unfortunately, will it reduce frequency ? In my limited knowledge and am quite happy if someone corrects me, metabolism isn’t a linear equation. So, your body today might says thanks for the the 1.2 ml, goodbye 0.8 ml. Another day, it may say thanks for the 1.5 ml, see you later 0.5 ml.

We are all individual with our own symptoms and recovery.

Best wishes

Thanks all for the replies

From what I have read, it would be any use because your body expels the B12 it doesn’t need. You can’t overdose on it though…..

pvanderaa profile image
pvanderaa in reply to Libuse

For me, the goal is to make it to the next injection without going into the deficiency. When I’m deficient is when nerve damage continues it’s relentless march. Splitting the dose, although not as strong per injection, loses less down the drain from peeing it away.

I think that, when your body loses the ability to recycle B12, you just become a consumer of it and making it last becomes the long term strategy. Things like stress and worry, as well as physical exercises, and mental exercises, all use up molecules in the blood that then consume B12 to refresh and process. But this is normal life and the more you do, the more B12 you consume.

Also, by using a logbook, and noting the symptoms and their severity for the three days after the injection, I’m able to measure how deficient I became before the injection. Some people seem to think that they are having a reaction to the B12 injection. I’m of the opinion that these are symptoms from nerve repair or excessive metabolism making up for the backlog that occurred while I was deficient.

I’m always trying to find that happy median where everything is back in balance.

lindajanes profile image
lindajanes in reply to pvanderaa

Your approach of splitting the B12 dose and doubling the frequency interests me. Thank you for bringing it up on this forum. Even with weekly injections, I experience some roller coaster effect. When injections were every 2 weeks, the roller coaster was definitely plummeting down for the entire second week. Increased nerve damage was the result. Like you, I have decided that being more tired for 24 hours after some injections just means my body is working extra hard make up for a greater than usual depletion. Your logbook idea is a good way to review that situation. Thanks.

pvanderaa profile image
pvanderaa in reply to lindajanes

To monitor progress with the logbook, reset to day zero on each injection and compare severity of the symptoms on day 1 with those from day 1 in previous cycles. This way you eliminate the roller coaster that impacts day for day comparison.

I have long questioned the dosing of B12. Lower doses, more frequently, might prove better - at least for those who are not at the every other day/ every day level. Imagine 50 micrograms a day instead of 1000 every two/three/four weeks?

To this end, I thought of two things. One is a micro-injector - but I simply can't find a picture! A needle with an attached tiny bulb which is pressurised. (I thought they used something like that when the blood transfusion people used to offer anaesthetics.)

Or a non-needle injector, such as:

portalinstruments.com/produ...

Cost might rocket - I can't imagine special B12 supplies not costing much more than standard ampoules. But it would be good to know that someone had done the basic research on dosing regimens.

Lollipops35 profile image
Lollipops35 in reply to helvella

Yep, try 1mg Hydroxocobalamin every 3 months with neurological symptoms 🤷‍♀️ (doctors are puzzled 😂) it’s a legal death sentence for the U.K.

I think you need to make sure you’re injecting in the right place. I believe I read that the deltoid will only take 1ml but perhaps double check that.

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