perniciousanemia.org/b12/in...
Whilst scrolling around I came across the above site. Probably known about by members - but not me !
Whilst many struggle to obtain adequate B12 treatment schedules it seems a UK lab is supplying the US ! Can this be right ? Surely not....it seems upside down to me. I appreciate mixing with saline could be a step too far for UK surgeries - perhaps it could be modified ? - providing regular treatment for all...
That is not a UK company/site. Though they do say:
This vitamin doesn’t come from some unknown Chinese source. It comes from a reputable, pharmaceutical-grade laboratory in the UK.
But as their product is methylcobalamin for injection, and that is not an approved product in the UK, it doesn't appear to be undermining treatment of UK patients.
Their contact details are:
Our address:
Pernicious Anemia Relief
PO Box 110
Tirat Carmel, 3910002
Israel
I don't think I mentioned it being a UK site ? It's very soon apparent it is a US site - well it was to me... I was merely thinking the info may/could be helpful for some - a possible starting point. Didn't mention the undermining of UK patients either. As all good research papers often state - more detailed investigations are required..... On reading I was hopeful the UK lab may open up other possibilities !
It read as if you were saying that the supplier link was to the UK lab supplying the US. Rather than a portal site. But I can see it either way.
The product appears to be identical to this:
Vitamin B12 – Methylcobalamin Services
£32.00
Each vial contains 40 mg pure pharmaceutical grade methylcobalamin in dry form. Please see our resources section for more information on vitamin B12. Please note that whilst we are able to ship worldwide, we cannot take payment here for shipments to the USA. Please email safety@oxford.bio
oxfordbiosciences.com/store...
Which has been mentioned many times. I would not consider mixing and using such a product over a month. But some do.
Thank you !
Marz is right that the B12 supplier that this company uses is in the UK. On the page they mention:
"We’re excited to announce our cooperation with a dedicated biosciences lab in England, UK. "
Most likely this is the often discussed powdered methylcobalamin from oxford biosciences that you linked above helvella.
They also make a bunch of nonsense claims about the alleged special efficacy of methylcobalamin but I guess one might expect that since they're selling the stuff.
As helvella says, it's Israeli, not from the UK.
It's actually quite interesting to see what it says about the need for injecting daily to get all the benefits, etc.
All the best to you and hoping you haven't had too much flooding where you are.
It's dry and (very) cold here in the east today!
Thank you - all dry here !
Thank you. SO SO cold here at the Leicestershire/Derbyshire border. Brrr…
A friend moved to near Queniborough about 18 months ago and I'm amazed by how cold it is in your area! Jolly wet, recently, too!I hope you're as OK as possible.
Yes it is rather cold at the moment. Luckily no flooding where I live, on a hill. Health not so good… Hope you’re ok.
I am below sea level by many metres , in the Netherlands but still keeping it dry.
Wow!Good to hear!
perniciousanemia.org is an American site. They get their powdered B12 Methylcobalamin from oxfordbiosciences.com . Oxford biosciences are actually mentioned on the site . They charge about 3 times the price that You would pay if you ordered directly from Oxford biosciences . American Buyers have to buy by means of an email , not in the usual direct way from the Oxford biosciences site , because of the agreement with perniciousanemia.org.
You are the font of all ordering knowledge!Thank you again for your wonderful help.
Just to clarify that, as Helvella and Denise mentioned in an earlier reply, the organisation that runs the site is based in Israel as you can see here : perniciousanemia.org/contact/
Pernicious Anemia Relief
PO Box 110
Tirat Carmel, 3910002
Israel
Yes I did r ead - thanks🤓 I think my first knee jerk reaction on reading the 'article' was if there is a UK facility producing B12 why is it such a struggle to obtain B12, in any form, on the NHS.
I guess living in Crete for 15 years where I could buy B12 OTC has left me despairing at the system here. I buy my thyroid hormones and B12 on-line and self-advocate. Fine atm but am concerned about the future as I become an even grumpier old lady 🥰 with less computer skills than I have now !!
In terms of B12 production/synthesis facilities , when I last looked into it, everything was coming from China apart from one facility in France. But I may not be up to date there as I havent looked into recently.
hello, as per helvella its Methylcobalamin available from Oxford Biosciences uk. I use them. The USA site has inflated prices. Best wishes.
Interesting and complicated. I think in the UK most people self-injecting will buy hydroxy cobalamine from Germany and pay about 18 Euro for ten x 1mg/1ml ampoules. Very easy, safe and effective. It should get converted to the methyl version inside you.
Methyl B12 is another proposition, much harder to find, more expensive and unstable as a solution, so you will have to dissolve it at which point its going to become unstable.
Its possible that some people might benefit more from methyl cobalamine than hydroxy. I dont know and I think the research is likley to be vague so I would say try hydroxy cobalamine.
Also using single ampouls of 1mg/1ml is safer in terms of keeping everything sterile. If you make up a large vial of methyl B12 and then take 40 doses from it your chance of contaminating it will go up pretty quickly unless you are very careful.
I agree on the multiple dose vials...it definitely needs to have something more than simply saline. Any MDV needs to have a bacteriostatic agent in it...not simply water. I have and do use MDV, but as you said...you must be careful! You need to be 100% aseptic, every time! No mistakes! If there is a mistake, you start fresh. Living in the US, with our inflated prices, as someone already pointed out, we must do things a little differently. I would love to have single dose vials/ampoules, but they don't really exist over here. Methyl B12 is only available at compounding pharmacies at extreme prices. My wife just renewed her prescription for it at our local pharmacy; $270.00 US for 18 ml!Keep researching and finding other sources for what you need and keep being your own advocates for your health! Stay warm and dry!
When evaluating stability of B12 I consider both the growth of bacteria and the effectiveness.
My study has led me to conclude that the forms of B12 do not differ with regards to bacterial growth. I discard the multi use vials after 28 days of first use. I store for 181 days once mixed with saline and then discard.
My study has led me to understand methylcobalamin is stable when stored at room temperature within the above limits.
However it is not stable when exposed to light. (This is not an issue if stored in amber multi use vials.)
The following is from a site called Phoenix Rising which is for CFS. The testing was done by an administrator.
“Exposed Methylcobalamin to fluorescent lighting for 5 min resulting in a 44.1% reduction in Methylcobalamin.
Exposed Methylcobalamin to fluorescent lighting for 10 min resulting in a 67.7 % reduction in Methylcobalamin.
Exposed Methylcobalamin to fluorescent lighting for 15 min resulting in a 83.3 % reduction in Methylcobalamin.
It converts mostly to Hydroxocobalamin.”
I have done trials of Hydroxocobalamin, Cyanocobalamin, Adenasolcobalamin and Methylcobalamin and various combinations.
I have concluded that for my body Methylcobalamin with Adenosylcobalamin best meets my goal of healing to the greatest degree possible. I would not use any other forms based on my healing although I allow my body is healing and what treatment may be best in the future is unknown.
I do my risk evaluation based on risk vs reward and do not use the method of eliminating as much risk as possible and disregard possible benefit. Understanding risk is inherent in any treatment and outcomes are unknown. Started that when I did my first injection which had risks.
Thank you ! Wow...
Can you please tell me the difference between them all? I’m in US. There is no compounding pharmacy near us to get Hydro and ordering from NJ was quite $$. We have a friend who works in Canada that gets us OTC Cyanaclobamin for very inexpensive and brings them for us. Also that seems to be the type dr’s in US mostly prescribe for B12. Ty.
"Can you please tell me the difference between them all?"
I wish I could. Having found no information that I trusted to lead me to the most effective form of B12 for my body I chose to determine it for myself by trials. There is much information but none of it is conclusive or based on a comparative analysis.
Wedgewood had done very nice work on how to obtain B12. It is still a lot of work and very frustrating.
I found it helpful to separate deciding what form of B12 to try from the logistics and cost of purchasing.
I dont think for most people there is much of a difference. I personally use methylcobalamin as it works for me but single use ampoule at room temperature away from light. It is expensive though and many people on this group find hydro equally as good if not better
It does seem likely that Hydroxocobalamin is effective/appropriate for the majority although there is no information how many have done a trial of methylcobalamin and have the information to evaluate with a compare and contrast evaluation.
For my body at least most recently Hydroxocobalamin and Cyanocobalamin are equivalent and Methyl with Adeno is much more effective.
Then again oral B12 meets the what works criteria in that symptoms are diminished. Having been successful in self-treating to the point I would not qualify for a diagnosis of B12D by symptoms I am supplementing based on improved life.
PETITION TO BE ABLE TO BUY B12 INJECTIONS AT YOUR LOCAL PHARMACY IN UK !
Hydroxo-B12 in the US?
Sore cracking lips reaction to b12 injections
