My inflammation.

[WIZARD6787]

I am not using the medical industries term. I am using the term inflammation to describe my symptoms of stuffy head and theeth ache. It feels like my body is attacking itself. I can cause my inflammation with physical stress which is not acceptable to me. I chose not to accept I have to live life in a less desirable way.

My goal is to experience being tired or even exhausted and not anything else.

So I came up with inflammation as the last 'symptom' that I need to address.

Medical industry was easy. Sucks to be you and all you can do is mitigate. We can medicate but the results are not known.

The concept of must be toxins, life style bla bla bla is treating the world and not me. The concept that what I experience can be treated with life style is invalid to me and that is from mitigating what I experience my whole life until it got so severe even the medicial industry could recognize it. And yes I thought I was doing a wonderful job of it. No way I could have known there were other possibilities.

So I have been looking at what the supplement industry is doing and comparing it to the medicial industry. I was surprised at the cross over in what I am currently supplementing, what is recommended for other autoimmune disease and the work of the supplement industry.

The supplement industry is using applied science much in the same way that the medicial industry does.

There are claims of great results by the supplement industry not dissimilar to the medicial industry other than the medicial industry claims mediocre results are all anyone can experience.

I do believe that some supplement protocols achieve great results where the medicial field fails. The flaw I see is the claim that everyone will experience great results. This is not dissimilar to those on the forum whose body needed less supplementation and achieved great results and preach to others that do not.

The supplement industry uses the concept of treating the root cause when the root cause is not known and is inducted from the results.

I look for and create patterns. I noticed my eventual good results with NAD and that the NAD initially caused symptoms associated with B12 to reoccur.

I abhor taking pain medication and see it as a mask unless it is for something specific and short term I tend to only take pain meds when the pain is severe. I tried Ibuprofen when not in any pain and felt better. Not a solution simply information.

So what if autoimmune conditions are actually inflammation? What if B12D and PA is the result of untreated inflammation? It certainly would not be known.

In this moment it feels like my self treatment of B12D is more about treating the results of inflammation.

With my understanding of biochemistry which is in part from my work and study as a environmental scientist I do not use the term co-factors and am wary of precursors.

I can see both the medical industry and the supplement industry as vendors. This helps with my evaluation of their rhetoric. It also helps to understand that vendors that are successful believe in their way.

I still have more work to do with my understanding of how to treat what is labeled as B12D so there is no action to be taken at this time. I am doing the review/study to determine if I feel inflammation is worth exploration and discovery. I have concluded that the medicial industry will likely be little help with any exploration or discovery.

If I decide to preform exploration and discovery of supplements sold/recommended by the suplimentation industry I can apply some of my philosophy gained from my discovery and exploration of B12. Specifically I find it more effective to start with a higher amount than a lower amount. I understand the correct dosage is unknown. I find it more effective if I block out a week where I can deal with any disruption. I can expect my symptoms of B12 deficiency to return if the supplement is effective for me. I will review the information given by those in the supplement industry from he view of they are a vendor.

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From my work it makes sense to me that medicial personal can not diagnosis fatigue. Fatigue is listed so often as a symptom for so many conditions it makes sense it is not seen as a definitive diagnosis and any other possible diagnosis indicated by testing will be considered the best answer.

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It is miserable weather so I am going to keep writing so as not wanting to when the weather is nice. 🙂

I find it helpful to see the medicial personal as likely narcissistic and have found surgeons to be psychopaths. Not a big fan of name calling. I use the term to likely predict behavior, watching for the exception.

One on the things I found invaluable from those that shared is the understanding I am not being singled out. It is reasonable to expect that a relationship with anyone in the medicial industry to be abusive and controlling. Never wrong and defensive or aggressive when shown to be wrong or even questioned.

I am a white male and well educated. I can not only expect to be treated with more respect I am used to it. When I meet with a medicial professional it is cordial and sometimes I am excited that they may actually practice medicine. I get their notes online and their notes bears no resemblance to what happened. It was once said I am going to put you on blood pressure medication. To which I replied I follow the protocol of the American Heart Association and measure through out the day and blood pressure medication is not recommended. In the notes it is paticient refuses to be treated for high blood pressure. I write my own notes on my chart and make the correction. The result is that hematologist does not want to see me anymore. That is just one example.

I as best I can get angry and express then go back to what I can expect.

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Going slow is not THE way to go it is A way to go. I see going to fast or to slow as both errors that can not be prevented. I do not prefer one error over the other.

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I am comfortable with the ambiguity of self treatment and find no comfort in following others just because they do not have any ambiguity. I hate it but am comfortable with it.

[Wwwdot]

Hi Wiz

Phew!

Another mega packed post.

I am on the same page with inflammation- I am researching along similar lines.

I will read and digest - busy busy at the moment - trying to enjoy my plateau!

🤗🤗🤗

[WIZARD6787 in reply to Wwwdot]

>>Another mega packed post.

Or the ramblings of a mad man finally spinning into the black hole of insanity. 🙂

[Myoldcat]

Thougt provoking as always WIZARD6787. Surgeons as psychopaths is an interesting concept- I imagine they need immense self belief and fairly huge egos to undertake their work. The two I've encountered as a patient were arrogant and misogynistic, but thankfully good at their craft. I believe inflammation is definitely a factor in many of our modern lifestyle diseases. I've heard the term 'brain on fire' used for Alzheimer's and other dementias, although not within mainstream health. Some recent nutritional research has highlighted the crucial importance of B vitamins (especially B12) in reducing dementia risk, but it was noted they are only effective if sufficient levels of omega fatty acids are present. Apparently the combination reduced brain shrinkage by 73%, and it's worth noting that the vitamins were given in higher levels than could be achieved through diet. Will try to find a link to the research...

Look forward to hearing your ongoing experiences.

[WIZARD6787 in reply to Myoldcat]

Here is the thing with intellectually gifted psychopaths for me. I can not understand as I do not lack what a psychopath lacks. I can observe and predict.

Surgeons routinely do unnecessary surgery and they feel no remorse. It is not they can ignore it rather they do not have that feeling.

As a consultant I was in demand and could choose my clients. I refused to work for dentists and doctors. Not I could not make money I did not enjoy it. I attributed it to arrogance. My understanding now is they did not understand I could not just make decisions without considering the effect on my clients. In short I needed to think and consider and they wanted to hire me to make a decree what the solution was and that was all that was ever needed.

>>but it was noted they are only effective if sufficient levels of omega fatty acids are present. That is thought to be true with the treatment of autism.

[WIZARD6787]

OK this is what happened. I felt like I was on the cusp of designing a Lazarath protocol. The remaining issue what I termed my inflammation. I did some work on that sort of kinda pre-exploration. It flamed out in that what was known about inflammation and the symptoms did not fit.

At the same time I happened to run out of NAD. When I took NAD the intimidate affect was a worsening of symptoms. I took this to be a symptom of healing and kept increasing the amount and the results were very positive.

As I had run out of NAD I decided to stop that supplement as a trial and my 'stuffy head' returned in 8 hours. I did not associate it with the stopping NAD. I had in my mind I was going to evaluate in 5 days when the NAD I ordered arrived. Incorrectly thinking that there was no way the stopping the NAD would have an immediate effect. I also attributed my 'stuffy head' to the weather and the stress on my body from having to deal with the colder weather.

Last night my symptoms worsened. It felt like here I go again. Looking back the night before was the start of it.

Although the NAD had arrived early so I had it on hand I chose to try the NAC I had on hand to get information. Expecting to go back to the NAD in the morning. NAC and NAD are not the same thing but when used together with other supplements are thought to lower Homocysteine. NAC is used as an antitoxin and anti-imfamatory.

I took 2000 mg in capsule form and within an hour symptoms had abated and I slept very well and feel Okish this morning.

As I have written I supplement 5 to 6 times a day. The reason is I supplement every three hours which is 15 to 18 hours. Sometimes I want to sleep and do not supplement the 6th time with the understanding that if my body wakes me up to tell me I need to supplement than I do. On those days it ends up being 6 times. It does seem that I do better on those days.

So with the new information from taking the NAC it felt like I had created chaos. It does led to a whole reevaluation of my self-treatment and likely a total redesign. Here is the thing with exploration and discovery. The exploration is by its nature chaotic. That leads to discovery.

It does seem to me that some see exploration to be finding someone who has the answer that is not the way I do it. I look for information that may be valuable in my exploration that leads sometimes to discovery.

You can not get to the moon by using the find what works method.

[Oneash]

As I understand it vitamin B12 is essential for accurate DNA replication. When DNA unzips and copies itself, errors can occur. If these are not fixed, mutation can be replicated. If errors are too great the cell dies - Apoptosis, if they don't you can have the start of cancer.

Thankfully, usually the body just cleans these dead cells away, with no inflammatory response, in fact in apoptosis cells can release soothing enzymes, so the immune system doesn't wake up.

But that unfortunately doesn't happen when the wrong sort of Caspase is activated.

This is where the science starts to go way over my head. nature.com/articles/s41418-...

Caspase is a form of protein that uses cystine to cleve peptide bonds, to break up dead cell structure. Some are calmed and some are stimulated by vitamin B12.

Too much Caspase - 3 and you provoke the immune system....... I think, do please tell me if I'm wrong!

Cystine is recycled from homocysteine in the liver in a process using vitamins B12, B9 and B6.

The immune system itself needs vitamin B12 to create 'killer' T cells.

Also...

"Vitamin B12 can be considered an endogenous negative regulator of nuclear transcription factor-κB (NFκB) through the regulation of nitric oxide, which plays a key role in regulating the immune response to infection."

pmc.ncbi.nlm.nih.gov/articl...

So that can go someway to explain why inflammation is caused by vitamin B12 deficiency and can get worse after we finally get enough.

And we are tired out because B12 is needed to generate ATP, the energy for all bodily functions , in mitochondria.

The more I go down the cobalamin rabbit hole the more I am amazed to see how it is used in every single complex function of our bodily processes.

[Myoldcat in reply to Oneash]

Yes, so critical that we should really have evolved to make our own! Design fault...

[WIZARD6787 in reply to Myoldcat]

Love it! A design flaw. What I want to know is why we ever came out of the ocean?

[Myoldcat in reply to WIZARD6787]

Maybe that was our big mistake...😁

[Myoldcat in reply to Myoldcat]

Just read an article on the Discovery website - apparently bacteria in our large intestine DO make B12, but as we can only absorb it in the small intestine we just poo it out. For goodness sake...🙄

[WIZARD6787 in reply to Oneash]

>>So that can go someway to explain why inflammation is caused by vitamin B12 deficiency and can get worse after we finally get enough.

Or inflammation or the way the genetic code is expressed causes B12 deficiency and when B12 is administered the body can now fight the inflammation. Not enough B12 or without the synergy of what else is needed to completely fight inflammation it feels worse.

I go back and forth with the exceptionalism of B12. Is it real or a scientific construct. The sun does not orbit the earth.

I also go back and forth of the defect concept of medicine. Does the body really malfunction or is it trying to do what it needs to do and failing and what is seen and measured as a defect is actually a response to an unknown task the body is trying to accomplish.

The more I study the more I know how little is really known and am stunned often the body works at all.

[Hockey_player]

For a stuffy head, you might also check for environmental triggers. I have problems with wool or down (feathers), old pillows can have allergens in them, must, mold, mildew, pollens, perfumes (that can be in things like soap, shampoo, lotion, leaning solutions), pets (when I visit people who have them). I use Tide-free laundry soap since I have problems with other brands.

[WIZARD6787]

I am aware.

My stuffy head is the result of B12 D as evidenced by successful treatment.