What do you think of this video on homocysteine?

[Oneash]

youtu.be/9lb_Js5KMq4?si=0sB...(Not working as expected?) watched this and wondered are our problems, fatigue, inflammation etc. to do with toxic build up of homocysteine?

I already take B12, of course by injection, B9 l-methylfolate and B6 (though not p5p sort in a larger dose). I take a methyl B complex too and vitamin D.

Before I go and buy a whole load more supplements, I was thinking Choline, trimethylglyphine, SAMe and MSM do you think they would help get some energy back, let alone clear some arteries?

Am I getting them in food anyway?

Thanks for any wise heads.

[Technoid]

Unless you have a functional deficiency, heart disease, thyroid issues, kidney disease, or inherited homocystinuria, I don't think it's likely you would have raised homocysteine while injecting B12 and getting adequate amounts of Folate, B6, B2 etc.

For those whose homocysteine tests high because of one of the above, some TMG supplementation could be useful. You should be easily able to get the rest from food. I'm not sure why the supposed answer to every problem here ends up being to purchase more and more supplements.

I'm not anti-supplements where they're needed but there's way too much of a fixation with them while at least some members of the forum have not the faintest idea what a healthy diet looks like. You can't supplement your way out of a bad diet.

If you're really worried about homocysteine, you could ask for it to be tested by your local GP, or failing that, get a private test. If it's not raised, you don't have to worry about lowering it.

[Oneash in reply to Technoid]

Thanks Technoid,

I do eat a reasonably healthy diet. I guess I got a bit fixated lately because of shifting from folic acid to l-methylfolate.

I still don't feel like progress is happening and do a ridiculous amount of sleeping at times. I can get tired very quickly, like a switch goes in my head and have had a couple of worrying moments when driving. Some mornings my husband has a hard time waking me up.

I'm feeling very frustrated. I've got some big decisions to make.

[Technoid in reply to Oneash]

To be honest, if you look at my early posts I was all about every supplement I could get my hands on 😆. Comes with the territory. I think there's points where some supplementation is warranted but for the most part supplementation is overrated.

Fatigue seems to be the most common long-term complaint of many people with PA even with adequate treatment. I don't know why that is but is something I am often thinking about why that would be.

[MorningMist in reply to Technoid]

It’s easy to assume that with the right diet and supplements we can have boundless energy. I expect we all have an optimal level determined by our genetic makeup.

I do all I can to get enough exercise, sleep, eat healthily without unnecessary additives etc and yet I’m aware that there’s an underlying pattern that I don’t seem able to influence. There are weeks when I sleep well and feel really positive and then for no apparent reason I have disturbed sleep, increased resting heart rate etc. Optimal seems to be the best I can aim for. But I’m not sure what that is!

[WIZARD6787 in reply to Technoid]

>>You can't supplement your way out of a bad diet.

Thank you for sharing your personal opinion. As I understand it your diet requires supplementation to be 'healthy'.

>>I'm not sure why the supposed answer to every problem here ends up being to purchase more and more supplements.

No reason for you to understand self-treatment not related to diet.

[Gambit62 Administrator]

I'd be a bit wary as the presenter links to a supplement store.

[WIZARD6787 in reply to Gambit62]

>>I'd be a bit wary as the presenter links to a supplement store.

Studying supplements is the wild west right now. Profitable

Medicine is just this side of prehistoric. Profitable

Doctors in the USA attempted to get MNM be a controlled substance by slightly modifying the molecule and started testing it. The supplement industry was able to prevent that because if a supplement was not developed by doctors the FDA can not at this time control it unless it is shown to be harmful.