I decided to do a trial of Berfotiamine after reading randomized trials for peripheral neuropathy in diabetics. Yes there is work with efficacy done, just not with B12 deficiency. 1mg EOD is good enough treatment and the maximum ever needed.
I no longer experience peripheral neuropathy due to my supplementation of B6. It was agony prior to my self treatment with B6.
However, I see all my symptoms as neurological.
The electricity and therefore heat at my house went out and I woke up in peripheral pain. I injected B12 and the pain went away and I slept. This was a one off but I considered that I was not as well as I thought or I would not have been in pain. This led me to this trial along with actual testing for efficacy even though it was specific to diabetes. There is no competent work being done with improved treatment of B12. It is stalled at EOD and using RDA's as a measure which is not legitimatie for treatment if at all. It is legitimized by bureaucracy not scientific testing although some science is used as a justification for the bureaucratic platform.
I took 300 mg Benfotiamin at noon and then the next day started 300 mg twice a day.
I immediately felt my feet were 'buzzing' the next few days my back hurt a bit, I was sneezing a lot which is not typical for me, I started to burp and I do not burp. By day four I was having quick very painful headaches which progressed to sharp pain in my neck one side and then the other. None of these symptoms were overly distressful. I seemed to be breathing easier but this was subjective. I use the assumption that if my body changes when I administer a water soluble vitamin with no upper limit that is a sign of healing. This is an assumption on my part and has been shown to be true over time for me.
So I stopped the trial as I wanted more information from my administration of B12 by injection. "You do not rise to your level of goals you fall to your level of system." So took the information from my 5 day trial and went back to my system. NOT find what works.
I also reviewed the following pubmed.ncbi.nlm.nih.gov/102.... It is just an abstract and from Pakistan. It is fraught with the possibility of misinterpretation when reading work from another country. That is true in my field of environmental science even from state to state and between english speaking countries. That is my field so I can deal with it.
I have two more trials to do with injecting B12 and once I have the information from that I will revisit my other supplementation. Resisting the draw of simply finding what works although that will obviously be the result, it is not my system/method.
I also reviewed pubmed.ncbi.nlm.nih.gov/102... which again was done with diabetics for the efficacy of benfotiamine dosage. I noticed that the trial included twice a day. Good applied science.
I am having to work very hard to stay with my system and not look for the quick fix without the information I need long term. Oh bother.
My read on cofactors is that they are the result of petri dish analysis only and no trials of efficacy have been completed and amounts, frequency and concentrations are not credible. A failure to follow up on the information gained from the petri dish analysis. When not dealing with credible data humans tend to under do as a way to not make errors that result in damage, an emotional thing.
I found this helpful; I have read often that peripheral neuropathy is symmetrical and this is not the case with me. I am guessing that is written to make sure that the cause of the peripheral neuropathy is not a stroke.
I also do not put great faith in that the testing for levels of any vitamin or mineral is useful to determine efficacy.
I also wonder if the concept that some vitamin or minerals are use up when supplementing B12 is not really that is how the body adjusts to under supplementation of B12.
I am considering a trial of oral supplementation only. I now have the experience and information to evaluate that regimen.
Pretty much I am closer to where I want to go it is a time for tenacity.