Hypothesis XII

[WIZARD6787]

Hypothesis XII

The reason I write a hypothesis instead of using what if or it might be is that it is laborious. No way do I have the funding or experience to prove my hypothesis. The reality that no expert is going to try and prove or disprove it is inconsequential. I very much only write as it helps me and if my writing leads to someone else coming up with their own hypothesis. Bonus.

Hypothesis: That the retention and ½ life of B12 is based on the protocol used for medication and not scientifically valid and may be harmful in that it increases the length of suffering for some and never ends it for others. That it is important to facilitate possible healing that the body does not experience hours of not enough B12 to heal.

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I am aware I have written on this before when working on the other hypothesis.

If this hypothesis is correct and the amount of a 1 mg injection that is available for healing is much shorter than the 48 hours AKA EOD assumes it is, a whole lot would make sense. Which does not mean it is true.

To make it easy say it is 6 hours that a 1 mg injection provides healing. We are all different and 6 hours out of 24 might be enough to heal completely eventually. Others will not heal.

Now say injections are done twice a day 12 hours apart. We are all different and 12 hours of healing might be enough to heal eventually. Others will not heal.

And so on.

That it takes years to heal makes no sense to me and is not explained other than we all know that to be the case. What about the human body would cause a two year recovery other than not enough supplementation? Again if there is no reason given it does not follow that it is not true.

If correct, the current protocols are in effect insufficient for healing. Which would be a possible explanation for the being able to use up B12. One would be actually using up the amount of B12 available for healing. So using the EOD method it would be possible through activity to use up the 6 hours available for healing.

If correct it could explain why some inject once at night and in the morning and experience improvement. It seems to be typically two different forms of B12 and the reason for the improvement is not the different form rather more healing in 24 hours due to availability of B12 for healing.

It is also possible that we are all different and that we all can use B12 effectively for more or less than 6 hours. It is also possible that we all need B12 injections every 6 hours to efficiently heal and what is different is the amount of damage done and therefore more healing is needed. It is very possible the years it takes to heal is inefficient potocals.

It is also possible that .5 mg a day would be more effective than 1 mg EOD

I am also assuming per my last hypothesis that the human body only signals severe B12 deficiency and any hours the body does not have enough B12 to heal the body may not send signal/symptoms that more healing can happen. It is possible that with injections 6 hours apart the body can send signals it is healing.

In summary the current protocols are a minimum healing for some and others never enough.

This is just a hypothesis and ignores healing too fast and not having the correct cofactors.

It could also be that the reason that the body depletes potassium and magnesium is caused by under-supplementation and not by the actual B12 being ‘used’. The body is adjusting to having a bit more B12 but not enough.

It is well known that there is no lab test for the effectiveness of injecting B12. The only test is based on a reduction or elimination of symptoms. Limited to the frequency and amount that is practical in a clinical setting. Those of us that self-inject have no such limitation.

I will be finishing a two week trial of every 5 hours including setting an alarm to inject in the night and will post my results when it is completed.

I can report that I injected every 4 hours and then slept for two weeks and then injected every 5 hours setting my alarm and the rate of increased improvement was dramatic. The most effective protocol to date so far by far. The amount I injected in a 24 hour was the same, the only difference was the number of hours my body had more B12 available to heal.

If a medical expert had come up with my hypothesis and it were proved by tials it would be a medical breakthrough.

I am confident enough to use my hypothesis as a principle to design my next trial.

It is not yet wonderful. It is a whole lot more effective which could lead to wonderful experiences.

Or it could just be a two week blip. Creative thinking, exploration and discovery is like that. I do not expect that my hypothesis can be contradicted. It certainly can not be contradicted by we are not all the same or it takes time. That is irrelevant. That some people have more severe damage which needs to heal is very relevant.

The every 6 hours 1 mg is only for convenience in writing about frequency.

[Orchard33]

I think the distinction between healing and having a half-life, which is what the NHS protocol gave me, is a crucial one, if only because B12D/PA emerges so slowly and by the time it is seriously symptomatic a lot of damage has been done. It is heartening to know we can get better with this condition if we get the right, comprehensive treatment. Formulating the right treatment for each individual sufferers is why this forum has been so crucial for me, for which a heartfelt thanks to one and all, a happy Christmas and may 2024 bring progress and ongoing recovery for everyone🙏

[WIZARD6787 in reply to Orchard33]

🙂

[Hockey_player]

I agree with you that current protocols are not enough for some people. I see people who have neurological symptoms and they are being injected a lot less often than every other day or every day. The current recommendation for long term treatment seems to be once every 3 months. I suspect that is enough for a vegan who does not have PA. But so many have reported here that this is not often enough to keep the symptoms at bay. Some of us find this forum and end up taking matters into our own hands. I think there are many others who are undertreated and end up with permanent nerve damage, and a lack of energy as a result. It would not surprise me that doctors would blame the malaise just on getting older and miss the connection to inadequate B12.

[WIZARD6787 in reply to Hockey_player]

It has not been established that any protocol is sufficient for anyone. Only that is good enough for the physician.

We here have established that the current protocols are harmful to some in that they prolong pain and suffering.

I find it more likely that the reason vegetarians are more likely to have a diagnosis of B12 deficiency is that they are more likely the physicians consider B12 deficiency than in other populations rather than any scientific justification.

[Hockey_player in reply to WIZARD6787]

It took me 2 years of suffering before my B12 levels were tested. My initial doctor told me it was all in my head and thought I just did not like teaching. I just did not like teaching when I was feeling horrible (and vomiting). That was the last straw for me and I stopped seeing her (she had also missed a diagnosis of a neck injury I had and I suffered many years with that). But then it took awhile to get another doctor. Vegetarians who eat eggs still get B12 in their diets. Vegans need to supplement with B12.

[WIZARD6787 in reply to Hockey_player]

>>Vegetarians who eat eggs still get B12 in their diets.

Vegans need to supplement with B12. Not established other than conjecture.

[Hockey_player in reply to WIZARD6787]

I agree that there seems to have been a total lack of research for determining the amount of B12 needed to keep people healthy. There is also a problem that currently guidelines recommend EOD yet doctors might only be giving injections every few weeks or months.

[WIZARD6787 in reply to Hockey_player]

>>I agree that there seems to have been a total lack of research for determining the amount of B12 needed to keep people healthy.

It is not a matter of volume. More resources does not solve all problems and often causes more.

You can not agree with something I wrote that I have not written.