Methyl & hydroxo.

[qwertystar]

I’m injecting methyl 3 times a day. I’m also injecting hydroxo.

Should I be injecting hydroxo once or three times a day?

[Nackapan]

There's no answer anyone could give to that question. We all find regimes we can function on by trial and error .

[qwertystar in reply to Nackapan]

I’ll just wing it and see how I feel. I’m injecting hydroxo and methyl 3x a day and not having any bad side effects

[Nackapan in reply to qwertystar]

Is your body not reacting at all?

[qwertystar in reply to Nackapan]

Very slowly

[Kennyatw]

My naturalpathic doctor wants me to inject it twice a week because she says my B12 levels are not high enough but my regular pc says my levels are fine so I'm listening to him instead

[qwertystar in reply to Kennyatw]

what are your current levels?

[Kennyatw in reply to qwertystar]

My level for the bloodwork for the B12 was 84 which my PC didn't say anything about that so I'm assuming that if he thinks it's really low he would say something to me

[Narwhal10 in reply to Kennyatw]

Kennyatw,

It is a number on a screen, it does not tell me anything of your symptoms or what is going on at cellular level.

So :-

The colour drained from her face and I could see that she was loosing her balance. I quickly broke her fall, whilst she was on the ground, I knew she was breathing, I checked her pulse on her neck with my fingers. I gently called her, she came around. I asked whether she was hurt, checked her over. Got her to sit up, she was on iron tablets but had over done it Christmas shopping. People forget to listen to their bodies. It is not an unbreakable machine and it takes time to heal.

Patience is required. Keep a symptoms diary and you adjust your individual frequency to your own individual symptoms.

PRN in medicine stands Pro Re Nata, as and when required. You have one fingerprint as does qwertystar. Your needs for Hydroxycobalamin Methylcobalamin and cofactors will be different due to :-

1) Age

2) Gender

3) Height

4) Build

5) Metabolic Rate

6) Length of deficiency

7) Severity of deficiency

8) Other illnesses, diseases, conditions.

9) Cause of deficiency, if it is functional, Pernicious Anaemia.

Many organisations are trying to dispel the myth of re-testing B12 levels when treatment has started. Please start reading around the subject for a better understanding of the disease and condition and think about what you post in the Public Domain. Some information I read is dangerous.

[Pickle500]

That's alot of injections.

Your body may just pee alot of it out.

Consistency and time is the best remedy. Or do you have a reason for the high number of injections?

[KBonBoo in reply to Pickle500]

Agree. Interested why you're injecting anything three times a day. Also, methyl should be comined with adenosylcobalamin for best results.

[WIZARD6787]

I have reviewed the retention times data in depth. They are not measuring effectiveness and not measuring someone with B12 deficiency. They are used to determine amounts and frequency and I do not find them credible to make any decisions.

I have used 4 forms up to 8 times in a 24 hour period and have had no side effects. I have experienced healing which is not all roses and have hung in there and not gone with I was having a reaction.

There is no credible information about one form or another or about the effectiveness of any amount.

I have found that methylcobalamin to be the most effective and causes the most change which is my goal. The changes are not roses.

I injected 4 hours apart 2 mg at a time and found all other amount to be not only a lot of injections but not conducive to healing the damage to my neurological system or the harm of undertreating for three years.

All ideas about taking a long time reference current treatment.

I recently decided to inject 2 mg every 5 hours including setting my alarm to get up in the night. My thought based on all I know is that it might be best to not have my body be without B12 for how ever long I slept. It has only been 6 days. Unless there is a drastic change less amounts less frequency is too little and not a lot.

B12 is excreted in the urine. It is not known to increase urination. Peripheral neuropathy is known to increase urination. I experienced an increase of urination as my neurological system healed on too little B12 until I injected 2 mg every 4 hours and then it normalized.

I compare different forms and frequency as that is the only way I know how to get information I value. Oral cyanocobalamin works. It is the least effective.

[qwertystar in reply to WIZARD6787]

Thank you for your reply. I feel that methyl has been a lifesaver for me. Hydroxo on its own didn’t help.

[WIZARD6787 in reply to qwertystar]

Thank you that information's very helpful.

[ShawnH in reply to WIZARD6787]

Additional notes: B12 will decrease potassium levels which will increase urination and thirst. Hypokalemia is serious and that is why 4800mg of potassium is recommended daily with B12 shots.

The rate of excretion of injected B12 in urine varies by type (less excreted with hydroxy than cyanocobalamin). Half life also varies depending on type. This information is easily found with an internet search.

Cofactors are critical for absorption. Folate is necessary for B12 uptake but if severely B12 deficient, can actually deplete B12, so one must be careful about figuring out their optimal dose for B12 uptake.

You shared detailed and excellent information btw!

[WIZARD6787 in reply to ShawnH]

Thank you for that. I had not considered potassium with regards to urination.

I did some research on the testing to determine retention times.

The results vary from individual to individual and the rates are an average of the general population and not correlated to effective treatment other than higher retention may be better. Nor correlated to someone who is or has been B12 deficient. If shorter retention was caused by more absorption that would not be known. Same with half life.

I expect what is done is the testing and conclusions follow the methodology for medication and that may or may not have any value to decisions on form, amount and frequency to heal a body from having been B12 deficient and undertreated. I do not consider retention times or half life anymore and work with effectiveness as established by personal trials as an overriding factor.

At sometime I want to do more work on the known cofactors. I want to review each one starting with the reliability of each test with regards to actual deficiency. I know so far that B12 and B6 tests should not be used to eliminate deficiency.

I would include toxicity in my evaluation.

Flipper and I did some work on the science of finger prick science and I conclude which Flipper does not that the finger prick science is applicable to monitoring levels and financially justified.

Then I would like to research optimum levels.

Then I would design a testing protocol instead of the current wing it testing done by each individual practitioner.

A cofactor testing protocol designed using rational methods. A rational co-factor supplementation protocol would naturally follow. It would never be perfect and symptoms would have to be considered. It would be a better place to start than where things are now. It would also make it more reliable to determine what B12 supplementation is effective.

There also could be errors in the available information as there are with B6.

I may never get to it as I keep hoping someone that gets paid to do the work will do it. Hey it could happen. 🙂

Thank you for your kind words. My work here is self-serving in that it helps be to write things out. And it helps me when others review.

[PhilAB]

You are injecting a lot. I inject one hydro in the morning and one methyl in evening. Although my methyl is 5mg per day (due to ordering to much).

When I started this regime in August 2020 Jesus did I have horrible reversing out syndrome. Honestly, it was a mental and physical battle that I did not think possible. But boy did I heal.

I think it is amazing you have no bad symptoms, it perhaps means you have not got neurological symptoms.

How are your folate, and ferritin levels. As these are crucial for b12 absorption.

Also make sure you are consuming food that is high in potassium.

I would also recommend iodine daily as well. Are you tired at all?

[qwertystar in reply to PhilAB]

I’m keeping on top of my folate and ferritin levels. I am currently unable to walk unsupported. I’ve recently started iodine. But while I’ve injected I feel no side effects. It’s like a surge of power goes to my legs after I’ve injected

[Wwwdot]

Hi qwertystar

Narwhal gave excellent advice in that only you know what works for you.

If you are self injecting you are rowing your own boat so you need to be prepared and learn as much as you can so that your self treatment is most effective for you.

No-one can advise what to take or when - only you by being aware.

🤗🤗🤗

[WIZARD6787]

Hey qwertstar,

10 months ago I started injecting 3 times a day. When I posted that here some indicated I was wrong to do so with no justification for that conclusion.

Just sharing a perhaps similar experience.

[qwertystar in reply to WIZARD6787]

I’ve experienced the same, but I shall continue, as it’s helping