Hi!
Looking for those wiling to share their experiences using Panpharma hydroxo versus Pascoe hydroxo. Please share specifics about comfort of solution (sting, no sting) during injection and whether you found one to work better for you over the other?
Thanks in advance!
I usually inject Panpharma but when it became difficult to obtain , I tried Pascoe for several months.
Despite the Pascoe being 50% stronger . I still needed to inject with the same regularity as I did with the Panpharma ampoule -1.00 mg
No stinging from either ampoule ( If you get stinging try numbing cream from Amazon )
Both worked equally well for me . I injected both Intra-Muscularly .
That’s it . !
Thank you Wedgewood! Good to know!
I’m quite sure that there are forum members with different experiences and reactions regarding Panpharma and Pascoe B12 depot . . We all react in such diverse ways . It’s very apparent when we consider P.A./ B12 d.. Just think of the different dosage regularity needed to keep symptoms at bay. Hope that you get some more responses . I’m interested to hear what others have to say on the subject . I hope that one day the mysteries surrounding P.A./ B12 d will be revealed. In the meantime , while we wait for that , this marvellous forum is a life-saver for us , who find ourselves in the wilderness of this condition . , which brought me to total despair .
I inject subcutaneously. Panpharma stings a little bit, though barely noticeable when injected very slowly. Other than that I don't notice any difference. I also don't know anyone who can inject less with Pascoe, just because the dosage is higher. IMO the more important factor is injection frequency, not the absolute dose. Some need to inject twice a day for instance.
Although I inject intramuscularly, I can confirm this. That is my experience as well.
I agree with you about frequency being the most important factor . I inject weekly . I would like to try injecting 1/2 ampoule of Panpharma at the same frequency , but would be nervous about keeping back the other half of the ampoule in the syringe for a week ( with a fresh needle of course) Better stick with what I know works .
The longest I've heard people keeping a loaded syringe (in the fridge and wrapped in tinfoil) is 12 hours. Any longer is not save I'd think.
I know of folk who will pre fill 7 or 10 syringes who are on EOD of daily. Kept in a dark draw once pre filled, no special wrapping up. I know there will be criticisms but they have been doing it for a long time and no adverse effects or loss of efficacy experienced. Swabbed injection area and needle.
I have used both subcutaneously and despite Pascoe being 50% stronger for the same 1ml dose I’ve not noticed any differences in effect. Panpharma stings slightly more but injecting slowly helps. It’s not unbearable.
The answers here have been really interesting!
I haven't used Panpharma but was initially prescribed 1mg in 1ml ampoules. They were of at least a couple of different brands, (one of which I think was Hevert, possibly?). I had to take a lot of sublinguals to boost my B12 intake as 1mg per day wasn't enough for me and I was unsure about doing 2 jabs a day.
As soon as I started using the 1.5mg in 1ml Pascoe ampoules I didn't need the additional sublinguals and really started to improve. I know a couple of friends who find they can inject 2x Pascoe 1.5mg, where they needed 3x 1mg injections daily before.
I've almost always found the Pascoe 1.5mg ampoules easier to snap, better to inject and all round good.
Be aware that Pascoe do 1mg in 1ml ampoules as well as 1.5mg in 1ml ampoules!
I think that frequency of use is more down to how quickly our bodies process each injection. I think the higher concentration ampoules are more effective for higher frequency injections.
Pascoe's 1 mg ampoules are cyanocobalamin though, so you can't compare them to the ones with hydroxocobalamin 1:1.
Yes , Pascoe do make 1mg x 1ml ampoules , but they are Cynocobalamin , not Hydrocobalamin.
Yes , you are demonstrating how diverse we all are , and that the “ one size fits all” treatment is totally ludicrous.
No, Pascoe offers both cyanocobalamin and hydroxocobalamin. Interestingly, the hydroxocobalamin is in a higher dose.
Cyanocobalamin 1000µg
10x1 ml PZN 1103262634
100x1 ml PZN 03262657
Hydroxocobalamin 1500µg
10x1 ml PZN 07568672
100x1 ml PZN 07568695
I now prefer Pascoe and have just ordered my second box of 100. I found Panpharma would sting a lot which I didn't like!
I hoped that Pascoe would last longer but it didn't. However, since I had a blood test and discovered that my folate level had dropped, I've been supplementing with methyl folate and I'm now able to delay injecting by 12 - 24 hours compared with previous frequency.
Did you have low folate to begin with or did it'll only drop after injections
Good question! I've only been requesting my folate is tested for the last three years, so I'm not sure. I've been self injecting for about 2 and a half years.
It is usually in the bottom half of the range and if I stop supplements it drops further. My latest blood test it had dropped from 10 to 6 (3.1-20). The highest it's been is 14 in 2022.
I also have Coeliac disease, so may have an absorption issue.
I've just found my blood test print out from 2014 when I was diagnosed with PA and Coeliac disease (already had Graves').
I was iron deficient: 4 (11.0-30.0) and my folate was 4.8 (4.6-18.7).
So I guess that answers your question.. it was low before I had my loading doses.
No one said a word about it and I wasn't prescribed iron either!
Both are fantastic. I inject SQ. Panpharma stings a little but zero from Pascoe. Same frequency with both but equally as effective.
I use Pasco 1.5 mg/ml. Inject every third day as that gives more or less the same dose as EOD 1mg/ml. This saves time and money. It works the same as any other. If you get stings its probably because you wipe with with an alcohol swab. I have never had a sting despite injecting ahuge numbe of times. BTW Pasco cyano also works well.
Appreciate all who took the time to respond. I feel like this is an excellent discussion and I’ve certainly learned a lot. Thank you!
Panpharma stings me horribly; I have the same reaction to any brand containing sodium acetate. Haven't tried Pascoe as I currently get my ampoules on prescription, but am very interested to discover whether the higher quantity of hydroxocobalamin would give a different effect. Does anyone know why Pascoe is formulated at a higher concentration?
I've been injecting IM Pascoe (Depot) both Every Other Day for past 2 months and Pascoe half dose every day separately over the same period as a trial. I've noticed a marginal improvement with every day frequency. Also compared Panpharma and Pascoe EOD with little difference. Both seem to sting if ampoules are cold but not usually when brought to body temperature. I pre-fill 4 syringes and store in a dark box at room temp using a good hygenic routine. I don't swab now as this sometimes stings. I was recommended Pascoe because it doesn't contain additive ingredients. Sub-cut doesn't seem to be as effective as IM for me. Hope this helps.
Hydroxo sublingual overwhelming!
Hydroxo side effects?
