Cyanocobalamin

[Pixielula]

Advice needed please

So I usually buy and use hydroxy ampoules, I bought a new box of ampoules a couple of months ago and I have just discovered they are cyanocobalamin 🤦‍♀️ Will I be ok to use these, and what is the difference between the two?

[fbirder]

Yes, it will be fine to use them. Cyanocobalamin is just as safe, and just as effective, as hydroxocobalamin. The only difference is that cyanocobalamin seem to be cleared from the body faster, so you may need to inject more frequently than you’re used to.

Some people are worried about the cyanide in cyanocobalamin. While it is true that it can produce hydrogen cyanide, the amount from one injection is very small. Indeed, it is less than one-fiftieth the amount that can be produced from a single passion fruit!

[Pixielula in reply to fbirder]

Thank you for the reassurance, I did think it would be ok as I’m sure I read somewhere that’s the most commonly used in the USA? It’s tricky when your trying to order on a German site.... I once managed to order a load of B1 and had to throw it away 🤦‍♀️

[clivealive Forum Support in reply to Pixielula]

As fbirder says - it's perfectly safe - I've been on cyanocobamalin for over 49 years and I'm still "clivealive" coming up to 80 years of age.

I wish you well

[Pixielula in reply to clivealive]

Thank you Clive for the reassurance ....

[deniseinmilden in reply to clivealive]

Hi Clive!

Lovely to hear you're still OK.

Thank you for all your help and encouragement over the years - and it struck me it's obviously quite a few years now as I remember you were only 73 or thereabouts when I first joined!

All the best to you, especially for your approaching "big" birthday!

[clivealive Forum Support in reply to deniseinmilden]

Thank you deniseinmilden - yes next month I become an "oxygenarian" (or something similarly unpronounceable) which hopefully will improve my breathing

God bless and keep you safe ❤️

[deniseinmilden in reply to clivealive]

😁😁😁Thank you for all the pun fun and similar!

God bless you too! ❤️👍

[clivealive Forum Support in reply to deniseinmilden]

Reciprocated deniseinmilden to you

[Pixielula in reply to clivealive]

I joined when you were Clive alive at 75, so very pleased you are now actively chasing down 80.......

[clivealive Forum Support in reply to Pixielula]

Ha Ha Pixielula thanks. I think it's more catching me up

I guess now I shall have to think of a new rhyme to go with eighty matey

I wish you well and God Bless

[Pixielula]

Just did my first cyanocobalamin injection, hubby is home today “just in case” I only got the 1ml as well not the normal 2ml 😁

[Litatamon]

I have taken all three. Although many feel no difference at all, I felt a marked difference between cyanocobalamin, hydroxocobalamin and methylcobalamin.

But I also don't give much credence to my results either - besides hydroxocobalamin lasting longer, which is a fact - as I believe every body can process and react differently.

[Litatamon]

I have an off topic question -

My GFR has taken a hit. A big drop. And I have one kidney. Although I do not think it is the cyanocobalamin at all, there is no explanation so far.

So I have switched to hydroxocobalamin to err on the side of caution.

If I go back and forth between the two would the hydroxocobalamin counteract the cyanide in cyanocobalamin at all?

**Once again I do not have an issue with cyanocobalamin.**

[fbirder in reply to Litatamon]

As I said before, the cyanide you'll get from 1000 mcg of cyanocobalamin is minute -just 20 mcg.

That's the same amount as you'll get from seven apple seeds, 10 mL of prune juice or one-fiftieth of a passion fruit.

[Litatamon in reply to fbirder]

I understand that. And I know it is a fact.

But that wasn't my question.

My question was if I add cyanocobalamin back in with hydroxocobalamin will the hydroxocobalamin have any effect on the miniscule amount of cyanide?

[fbirder in reply to Litatamon]

Hydroxocobalamin is used to remove cyanide from the blood of people who have cyanide poisoning. So I guess it could reduce the amount of cyanide in your blood from almost nothing to a little bit less than almost nothing.

Cyanide is in the blood normally (there are a hell of a lot of normal chemicals that contain cyanide). In humans the normal level is about 2 mcg per mL - sciencedirect.com/topics/ne....

If a 1000 mcg injection of cyanocobalamin can produce 20 mcg of cyanide. And, if that 20 mcg of cyanide is distributed evenly throughout the 5 L of blood, then it will raise the level of cyanide by 0.004 mcg per mL.

Injecting 1000 mcg of cyanocobalamin will raise your blood cyanide level by no more than 0.2%.

[Litatamon in reply to fbirder]

"So I guess it could reduce the amount of cyanide in your blood from almost nothing to a little bit less than almost nothing."

Sublime. Laughing.

[fbirder in reply to Litatamon]

Another thought just struck me.

If there is 20 mcg/mL of cyanide in a normal person's blood, and 1 molecule of hydroxocobalamin can neutralise 1 molecule of cyanide then 1000 mcg of hydroxocobalamin can neutralise 20 mcg of cyanide.*

The hydroxocobalamin will remove the cyanide from 1 mL of your blood.

No wonder they need to give such high doses for cyanide poisoning.

*B12 has a molecular weight of 1355, so 1000 mcg = 0.74 micromoles.

CN has a molecular weight of 26, so 0.74 micromoles has a mass of 20 mcg.