CYANOCOBALAMIN injection?

[Wellington1]

Hi, I have just ordered vitamin B22 injections from Vitamin B12 Online because if difficulties getting my usual one from the Dr. I dont know what I am give by the Dr so have ordered CYANOCOBALAMIN. I dont know the difference between the different types available. Does anyone know whether these are ok?

[fbirder]

The doctor will use hydroxocobalamin, as do most of us here. My preferred brand is Rotexmedica - versandapo.de/vitamin-b12-d...

However, cyanocobalamin will work just as well, with the proviso that you may need to inject more frequently, so keep an eye on those symptoms.

[Wellington1 in reply to fbirder]

Thank you. Do you need to buy something to inject with as well? Sorry am new to this.

[Seth12345]

There is a lot of material online about the differences.. Some of it is scientific and some of it is anecdotal and opinion based. So consider the source of what you read.

In a nutshell, there are three main forms used for injection:

Cyanocobalamin

Hydroxocobalamine

Methylcobalamin

Rather than have me inject my limited understanding of the forms it might be advisable to pop this into a Google search.

It seems people might react differently to different forms. There are some differences in people's biology that allow them to process different forms differently. It's a complex methylation process. Once again you can Google that, but it gets very scientific quickly.

I started with cyanocobalamin as I'm in the USA, but I've now switched to hydroxo. My personal preference is to not use a synthetic form and I think I'm doing better with the hydroxo.

[Gambit62 Administrator in reply to Seth12345]

Seth12345, not quite sure what you mean by artificial form - all injectable B12 starts off being grown in vats - it isn't extracted from natural sources.

methyl and adenosyl are analogues of the two forms used in your cells but the process of getting B12 from blood to cells involves breaking the bonds to the cyano/hydroxo/methyl/adenosyl element off and then recombining it with methyl or adenosyl in the cell, depending on which form is needed.

The preference for hydroxocobolamin in some countries is probably related to 2 factors

a) those individuals who have a rare condition - leber's - that makes them particularly sensitive to the cyano element won't be exposed to this element

b) on average hydroxo is retained longer in the blood than cyano. However, this is an average and there is such a lot of individual variation than some people d retain cyanocobalamin longer than hydroxocobalamin.

[fbirder in reply to Seth12345]

I am a scientist.

Almost everything you read about methylation that isn't a scientific paper is balderdash. Here is an explanation why methylcobalamin is no different from any other type of B12. b12science.com/B12Science/D...

All forms of B12 are equally 'synthetic' including hydroxocobalamin. They are all made by the same bacteria, grown in the same vats.

[Seth12345 in reply to fbirder]

Thank you fbirder and Gambit for clarifying.

One thing I did learn about from a video from the PAS conference was the use of a "depot" form of an injection. Currently I am not using a depot form, but I will try them once I receive my shipment from Germany.

m.youtube.com/watch?v=CjJpA...(Not working as expected?)

Watch that at 9:00 minutes and at the end around 17:00 minutes someone asks a follow-up question.

[Cherylclaire Forum Support in reply to Seth12345]

Also interesting to see the questioner at the end who voiced fears about GPs leaping to treat B12 deficiency with tablets and ditching injections completely !

[fbirder in reply to Seth12345]

Unfortunately, I don't think you can buy the oil-based B12 outside of Denmark and without a Danish prescription. Complications with an oil-based formulation are much more common than with water-based.

People have been working on slow-release formulations of B12 for some time as a way of making an intravenous dose work more efficiently.

When you inject your B12 is gets transferred from the injection site into the blood within a few hours, so the blood concentrations go sky-high very quickly. And, because of the quirky way that the kidney works, a lot of it gets flushed down the toilet.

When blood passes through the kidney almost all of the fairly small molecules (smaller than proteins) gets filtered out. This filtrate is then passed through a tube where all the things that the body wants, like B12, is reabsorbed. Everything else goes out in the urine.

It's a bit like cleaning out your house by taking everything except for the furniture, then bringing everything that you want to keep back inside, leaving the stuff you don't want on the lawn for the bin men to pick up. A great argument against intelligent design.

The problem is that the reabsorption process has a limit. Only a certain amount can be reabsorbed. Everything in excess of that amount is eliminated. So, if you have a lot of B12 in your blood then most of it will be reabsorbed and a small amount eliminated. But if you have a huge amount in your blood then almost all of it gets eliminated.

Using a slow-release formulation (which is a much better term than 'depot') you 'flatten the curve'. Instead of having a massive surge of B12 into the blood, with most of it getting eliminated, you let it trickle in and little to none of it is eliminated before it can be stored. So one injection will last longer.

It's one reason why it would be so much better if we could actually absorb B12 orally, sublingually, or transdermally. Because then we could take a small dose every day - really flattening the curve. Unfortunately I cannot.

[Seth12345 in reply to fbirder]

Thanks for the detailed explanation... I appreciate it very much

[texans2002 in reply to fbirder]

Hey fbirder maybe this is a dumb question but im gonna ask anyways. You had mentioned that in large doses or high content in the blood that the majority of the B12 gets eliminated and very little gets absorbed. What if you break up the injection dosage as in half in the morning and half in the afternoon? You think that will make a difference in the amount absorbed as the amount injected is less and less B12 is in the blood which would theoretically make for better absorption?

[fbirder in reply to texans2002]

It will make a small difference. Not worth the extra risk of having the second half of the injection contaminated by bacteria or fungal spores.

[texans2002 in reply to fbirder]

Yeah i hear you on that.