Ive been taking cyanocobalamin injections for 6 weeks, once a week prescribed by the Dr. Ive noticed that mid week i feel it wearing off and want to start taking injections bi-weekly. The question i have is the other injection is of the methylcobalamin type. Will it be alright to take the 2 different types? Didnt really want to take the cyanocobalamin but thats the only type the drs prescribe. I took a genetics test and the test specifically suggested that my body needs the methylcobalamin type B12. I was given a 3 month supply (weekly) of the Cynanocobalamin so i figured id use it. After the 3 month supply is over im gonna switch over to just taking methylcobalamin. The cyanocobalamin seems to be helping, alot of my symptoms have got a whole lot better. Anyways will this be safe or should i just stick to one type?
Cyanocobalamin & Methylcobalamin Inje... - Pernicious Anaemi...
Cyanocobalamin & Methylcobalamin Injections
There is no genetic test that can tell you that you need methylcobalamin. I'm betting your talking about MTHFR. Here's an explanation as to why your MTHFR status cannot possibly affect the type of B12 you need. b12science.com/B12Science/D...
It shouldn't make any difference if you have methylcobalamin or cyanocobalamin. Methylcobalamin sometimes causes unpleasant side effects.
I would stick with cyanocobalamin.
Well i was just going off what the paperwork listed on the test. It broke down what each genetic mutation was with an explanation on what it affects. Then it gave suggestions on how to solve the problem. All the mutations that i had suggested methylcobalamin.
There is far too much rubbish on the interwebs spoken about MTHFR and methylcobalamin.
Was it Genetic Genie that gave you such rubbish advice?
No, it was a decent company suggested by my Dr.
Here is what one of the biggest DNA testing company says about MTHFR.
blog.23andme.com/health-tra...
Based on the existing data, scientists at 23andMe have concluded that people should not interpret their genotypes at the common MTHFR variants as having an effect on their health.
In order for a connection between a genetic variant and a health condition to be considered real and clinically meaningful, well-run scientific studies need to show convincing and consistent evidence for that association. As statements from multiple scientific and medical organizations indicate,[14] [15] that is currently not the case for the common MTHFR variants.
There are no known genetic variants that indicate methylcobalamin is any better than cyanocobalamin. The enzyme methionine synthase can not use methylcobalamin.
Im sorry i realized i put dr on my last post, i meant naturopathic Dr suggested the test. Well i have both types of genetic mutations described in the article you posted. Ive been suffering for over 2 years with horrible neurological symptoms that no one could figure out. At one time they thought i had MS. My neurologist kept want me to be on klonopin which i refused to take long term. I had a suspicion it was B12 deficiency but all of my Drs refused to listen cause my levels were in range. So i took it upon myself to do a genetics test and basically proved my suspicion. Took test results to neurologist and then and only then was when he prescribed me the B12 injections. So honestly if its debatable or not the mthfr gene that shown up on test persuaded my dr finally. So now i feel so much better and if thats what it took then im running with it all day. Thank you MTHFR,love you,lol.
Haha haha! A naturopath!
I should have guessed.
Sorry, you ignore me and I’ll ignore you.
Did i miss something here? I was just stating how i found out about my possible B12 deficiency and how i got my neurologist to finally prescribe me what i needed. You got me puzzled brother.
No you didn't miss anything. Fbirder has disdain for naturopaths. And the four years of schooling that they embark on.
I find it interesting. Why? So many of our GPs have missed the boat. One of mine had me misdiagnosed for years on end. Taking steroid sprays that "I needed for life". Specialists such as neurologists have told people here that they are addicted to their shots. Some MDs have little interest in hearing the subtle and not so subtle symptoms that could help their practice and their knowledge of what to look for in other patients. So that others will not suffer needlessly.
My naturopathic doctor changed my entire outcome. She is the only medical professional that gets b12 deficiency that I have had contact with so far. In fact, she let me know that her sister is fbirder's only go to expert - a straightforward medical doctor, and she had maybe four hours tops of instruction in b12 deficiency/pernicious anemia in all her years of study and residency.
Mine also got my vitamin d up from 7. 6 (19) to 30 (76??) so far. Life changing for my legs. A clinic GP, with all her schooling, first refused testing (I had a myriad of signs of very low d) and told me to just go take some vitamin d if that is what you believe. If I had followed her and not said "screw this ongoing ego-based medical system" and found my naturopathic doctor I wouldn't have known how low I was and traditional dosing would have got me nowhere.
My naturopathic doctor also persuaded my GP to investigate issues that she was not open to doing (And I had zero issues trying myself and had ). I honestly think I will find some critical information when the time comes.
So no texans2002, you're not missing a thing. It is just another lovely day in the neighbourhood.
Insert smile.
Oh and my sister's GP is a star with all her schooling.
She still thinks b12 levels, despite being given copies of the proper information, are a guide to normal (ie. F.I.N.E fine) findings.
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And after cutting off all shots during the virus because they not essential, has now reinstated pernicious anemia clients only. Absurd in general. And how does she know my sister doesn't have PA? Oh one Intrinsic Factor test! Has no clue how unreliable one go at the test can be. And no reason given why my sister has suffered for years (she is not vegetarian or vegan).
Could care less that my sister's symptoms are getting worse over time. Why? Because my sister was over the normal with her. Even though my sister had a 79 b12 reading registered from a couple of years back. Her office used to put her on shots, take her off when she reached "normal".
So let's give thanks to all the brilliant medical doctors abound. And crap on the naturopaths!
Hi Texas, I'm a Marylander. My understanding is that unless you have a double mutation on a single gene you do not need to take methyl B12. One mutation means that you MIGHT have a slightly decreased ability to process folic acid. Even a double mutation doesn't mean that you will definitely have problems. I would caution using methyl B12. I tried liquid oral methyl B12 supplement and it made me feel awful. For 24 hours after taking a dose I felt anxious, tired, unable to sleep, etc. I tried it a second time just to make sure it was the methyl and I had the same physical reactions.
Good ole USA, lol. Ive been taking methyl lozenges for about 6 weeks and actually been doing well with them. Hopefully thats a sign that i will tolerate the methyl injection. So are there any people who has done well with methyl or are they like the unicorns of this forum?
Hi texans2002 I guess you are not in the U.K.
I'm not medically trained but I also have cyanocobamalin injections every three weeks (and have had for over 48 years) and use a methylcobamalin spray in between and had had no ill effects from using both at the same time,
I wish you well
I take cyanocobalamin injections once a week and in between take methylcobalamin lozenges daily. Just felt like it wasnt enough. Want to get to where im injecting twice a week. Yes im in Texas.
No problem with using more than one form of B12.
In general the form of B12 being used should be pretty irrelevant because the process for getting it into your cells involves breaking the bond, combining with another protein and then recombining once back in the cell. However, there is a lot of stuff still out there dating back to before the biochemists figured out that part of the cellular transfer so may be that someone hasn't caught - particularly if it is a variant on the MTHFR gene.
Makes sense. Thank you.
I would suggest self injecting if you are feeling the difference mid week. I also inject Cyano, I’m in Canada and went out and bought a vial of methyl that I had the pharmacy make up for me. We only have one pharmacy in the city I live that can do that. I had one dose and that was the end of the methyl for me. I injected 3 times per for over 2 years now and am finally able to get away with 2. However any type of stress on the body and I definitely need that third one.
Hope you are feeling better soon.
Thank you. So you didnt do well using the methyl b12? What were some of your issues if you dont mind me asking?
Probably the same as me and a few other people. I bought 5 ampoules of methylcobalamin, just to prove to myself that there was no difference. I was wrong.
It made me feel irritable and nervous and just plain 'wrong'. It only lasted for a few hours, but it was enough to make me give away the other four ampoules. The effects were very similar to those I experienced when I took an experimental antipsychotic back in the mid 1980s. Why methylcobalamin should have effects similar to a dopamine antagonist I don't know.
Some have speculated it has a connection with mutations on the gene for catechol O-methyltransferase.
For me with methylcobalamin -
Couldn't sleep at all for the first twenty-four hours. Continual wired feeling, like adversely ramped up. Felt overly emotional. Feeling of dread that I had never experienced prior to that.
I get hyroxy every10 weeks from the dr ( in the uk) but I Can't last that long so at the 4 wk mark I take cyano every2 weeks till the official one again. This Is working brilliantly for me.
I wish You well and good luck!
Thank you. Im starting to think from everyones response that cyanocobalamin is more tolerated than the other types of B12 injections. Now im concerned cause with all the research ive done cyano was the least preferred. I actually went out of my and had a hard time finding a place that administered the methyl type. I go this morning for my methyl injection.
Lots of people think that cyanocobalamin is dangerous because of the cyanide.
It is true that it can produce cyanide - about the same as you'd get from seven apple seeds.
"I go this morning for my methyl injection "
Will be curious to know how it works out. Hopefully you will be one of those who don't get that wired feeling. Crossing my fingers for you.
Thanks for sharing that Sherlockthepup.
I have thought about using a similar approach. So personal experience, and successful outcomes, really helps.
I've not read anything that suggests one form of B12 is absorbed any better than any other form of B12 from an oral dose. The absorption mechanism is limited to just over 10 mcg in one go, and doesn't discriminate between different forms.
Yet it is widely claimed that methyl-B12 absorbs better. And that it gets into cells more readily.
I have never seen any proper evidence of either. That could well be my ignorance.
Good luck， its hard getting it right but when you do it will all get much better!
I had one injection and felt nauseous like I had never felt before. The anxiety was so bad I didn’t know what to do with myself which was already the case but this was multiplied to a degree I wouldn’t wish on my worst enemy. I have never felt anything but good on cyano. Granted there were many times I was exhausted not too long after my injection but I don’t get that feeling anymore.
Plucky, do you remember when the exhaustion stopped for you?
Thanks in advance.
On the methyl or cyano? On the methyl it was a one time deal and it was most of that day and I never touched it again. On cyano it stopped as soon as I started feeling some symptoms go away. Within a couple months but this exhaustion was NOTHING like what I felt with the one dose of methyl. So I’d say when I started feeling like I did long before all of this b12 deficiency nightmare is when the tiredness got so much better. I do however find that if I go too long between injections.....which sometimes happens......I feel like all I want to do is sleep the day of that injection. My husband jokes and says it’s probably because you waited too long and now you have all of these repairs to be made. He laughs but I think he’s probably right. I would never tell him that though 😉
Thank you. Appreciate the insight Plucky.
I believe everyone can react differently to each type. And then there was a man on here, that tried all three, that clearly stated he felt no difference. Obviously both are valid.
I have tried all three. Felt completely wired on methylcobalamin. Didn't sleep the entire first night. Done. Hydroxocobalamin, was wonderful in that I felt my consistent strength over cyanocobalamin. However I weirdly gained twenty pounds in less than a month (no change to anything and I realize might not have anything to do with hydroxocobalamin), my skin became horrid (one just has to push through apparently - I didn't) and I was more constipated out of the blue - hated that. I switched back to cyanocobalamin, but really gave hydroxocobalamin an extended go. Didn't let any of these issues just make me instantly stop.
Lost ten pounds in a short time off hydroxocobalamin and back on cyanocobalamin (once again might be a coincidence), skin is wonderful again and totally regular.
I have one kidney. And the studies scare the crap out of me because of that. But I have spoken to Clive, who has had years of cyanocobalamin and fbirder has shared some pertinent information as well about the cyanide studies.
I am now at peace that for whatever reason cyanocobalamin works the best for me. If I see changes in my kidney function, I will definitely make a switch.
(But once again for others reading I did feel the longevity/more consistent result of hydroxocobalamin - I was just too vain to deal with the myriad of issues)
And I too have the gene issue, double mutation. But I got a ton of pertinent information on here to help me let that go as well.
All the best to you. There are some here that take two types at the same time.
Texans2002,
Forgot to add that the black sheep cyanocobalamin took away about twenty-five of my thirty symptoms in a flash. So even when I am insecure about it I have to remind myself of that fact.
Also, we have two companies that produce cyanocobalamin here and one day the pharmacist asked which one I took to better. I thought it was a strange question. How could that be possible? He told me he had many customers that take to one or the other.
But I do take to one more in two important aspects. I realized without even thinking of the pharmacist's discussion. I simply realized over time that I felt stronger and more level after my doctor's office shot and thought how weird but left that thought. I later asked and voila it was not the company that I buy most frequently to self-inject.
Good methyl is really good. I know fbirder and some others hate it but if you want to compare try arnika Germany
Cyanocobalamin or methylcobalamin. what's the difference. 
Methylcobalamin injections?
methylcobalamin
Experience with cyanocobalamin injections? What’s too much?
B12 Topping Up Between Hydroxocobalamin Injections 
