Gout

[Mozza127]

Had results back from doctors, all the trouble from my pain in hands is from slightly high uric acid levels which im now on tablets but no better out moment,

wondering is their a connection between B12 & Gout

thanks

[fbirder]

Never heard of one.

A quick search found a few references that list drugs (including B12) as a possible cause of high levels of uric acid. However, none of them have references to anything useful.

I did find one throwaway that suggested high levels of uric acid went along with the burst of red cell formation when macrocytic anaemia is first treated.

This paper actually looked at B vitamins and uric acid levels and found no correlation in females. In males higher levels of B6, folate and B12 were correlated with lower levels of uric acid. mdpi.com/2077-0383/7/8/210/htm

I would say there is no connection.

[Mozza127 in reply to fbirder]

Thankyou thats a great helpthanks again

[Gambit62 Administrator]

The study quoted by fbirder seems to have looked at both dietary intake and serum levels. The opening paragraph of the discussion is

To the best of our knowledge, this is the first study to show an association between intakes of folate, vitamin B6, and vitamin B12 with HU, and the largest population-based study using a nationally representative sample in the US. As such, our results must be interpreted cautiously. In this large population-based cross-sectional study in US adults, we observed inverse associations between intakes of total folate, folic acid (Q1 vs Q4, Q5), food folate, and folate (DFE) in men, and intake of vitamin B12 (Q1 vs Q4, Q5), but not vitamin B6, was also inversely related to risk of HU in men. We observed a lower risk of HU with higher intakes of total folate (Q1 vs Q2–Q4), food folate (Q1 vs Q4, Q5), and folate (DFE) (Q1 vs Q2–Q4) in women, and we did not observe associations with intakes of folic acid, vitamin B6, or vitamin B12 in women.

They are cautious because there are some limitations associated with the methodology but the results suggested that higher intakes of folate were associated with lower risks of HU (hyperuricemia) in both men and women and higher intakes of B12 were associated with lower risks of HU in men but not in women and intake of B6 seemed to make no difference at all.

I do remember reading a study in the past, which is probably among the smaller studies mentioned in the notes that showed that whilst folate seemed to relieve the swelling associated with gout, high levels of B12 seemed to have the opposite effect.

[Mozza127 in reply to Gambit62]

So it could be associated with to much be 12 as I've never had it since my injections started

[Gambit62 Administrator in reply to Mozza127]

there seems to be a lot of genetics involved with gout - ie it involves several different processes. whilst it is possible that B12 might have some implications the involvement of several different genes and different variants on those genes mean that people may respond very differently. The study that was originally quoted by fbirder looked at links with homocysteine which would fit with inadequate folate intake being a factor - B12 not likely to be a factor unless there was a B12 absorption problem or long term (measured in years rather than months) dietary deficiency).Sorry I haven't been able to re-find the article on B12 in relation to gout - though it was a very old article, which means that further studies may have shown that the relationship that was picked up wasn't as straight forward as first appeared.

[Mozza127 in reply to Gambit62]

thankyou very much ,