Depuytrens Contracture

Does anyone know if there's a connection between Dupuytren's contracture and PA? Dupuytrens is also called The Viking disease, sounds like I’m going to get big and blond! unfortunately that’s not going to happen, as its when the fingers of the hand are pulled towards the palm caused by a thickening of the tendons, it's mainly seen in men but women do suffer from it, sounds like there's not much treatment other than surgery and that's not permanent but if anyone knows of anything that can help I'd love to hear about it

[Hidden]

I remember a few years ago reading that pure organic castor oil rubbed into the effected tendons helped with this,it maybe an old wives tale and some of them are best sellers lol,it’s cheap enough to try and doesent have the complications of surgery so you’ve nothing to lose.best of luck

[Hidden in reply to Hidden]

Worth a try , Thanks !!

[helvella]

It certainly can be related to thyroid issues:

Cakir M, Samanci N, Balci N, Balci MK. Musculoskeletal manifestations in patients with thyroid disease. Clin Endocrinol (Oxf). 2003 Aug;59(2):162-7. doi: 10.1046/j.1365-2265.2003.01786.x. PMID: 12864792.

onlinelibrary.wiley.com/doi...

(Only abstract freely available, I'm sorry to say.)

[Hidden in reply to helvella]

Well the old Thyroid's shot so makes sense

[Marz in reply to Hidden]

Are you being treated adequately for your thyroid ? Do you know the all important T3 level ? I have Hashimotos and a B12 issue - and lumpy bits in my palms that are tender.

[Hidden in reply to Marz]

Thyroid treatment not good as I don't seem to fit into those little boxes they like to put us all in, a very long story!! but yes I have PA, Hashimotos, Asthma, DC and a few other bits and bobs this getting old larks a laugh a minuet

[Marz in reply to Hidden]

I am also a member of Thyroid UK Forum here on HU. Many of us are on both ! Come along and check us out - you will be amazed at the knowledge and support. Many of us are older but that is not a barrier to wellness. You can click onto my username above and read my Bio - only takes a minute or two !

[Hidden in reply to Marz]

thank you so much I was a member for quite a while but because I'm better, far better undertreated, people seemed to get really cross with me, most people need more thyroxine not less I had a TSH of 79.8 and felt fine, but Dr got hysterical I obviously need thyroxine but nowhere near what they want to give me, if they give me what they want to give I'm a mad man and I do mean MAD. So I just worked out for myself what I need and my TSH it through the roof but for me it's that or insanity. It destroyed my career, what can I say thyroxine is really bad news for some people

[Marz in reply to Hidden]

Some of us take and need T3 - including ne !

[DRunnerchick]

There does seem to be a few research studies tied to gene 🧬 5 and 11 related to B12 and folic acid deficiencies causing PA/Dupuytren’s Disease. I’ll try to find the links and paste them back here later.

I was diagnosed with DD this year. I was diagnosed with seronegative RA in 2016 and “sort of” undiagnosed in 2017. So, don’t know if the RA is valid or not. Also, am going to get genetics test for erythromelalgia (in hands and also now starting in my feet). So my hands are a mess sometimes but, I don’t have the contractures, just the nodules in both hands. I have Stiff Person Syndrome which often comes with PA. So far, no PA for me but have had B12 and folic acid deficiencies but am so far able to maintain on 1000 mcg sublingual B12/day and 5mg of folic acid 1/wk x4 months on 2 months off. Still fine tuning since SPS is extremely rare and a recent dx. Hopefully some of that is helpful. I’m very tired and mostly rambling.

[Hidden in reply to DRunnerchick]

Many thanks hope things look better for you in the new year.

[Sleepybunny in reply to DRunnerchick]

Link about Stiff Person Syndrome for anyone reading this thread.

rarediseases.org/rare-disea...

Link about Dupuytren's contracture

nhs.uk/conditions/dupuytren...

[Lgw19sof]

That’s interesting I have Dupuytrens disease as well as PA , I’ve never linked the 2 before . PA came first , then the DD . Will research it a bit deeper now .And I will come back if I find anything useful out . Ps I’m a woman , and the hand surgeon said it’s very rare in a woman , and it must be a rogue gene . As no Viking history or anyone else in the family with it .

[DRunnerchick in reply to Lgw19sof]

Viking is a bit of a misnomer. Anyone with Northern, Western European or even some of the earliest settlers in North America came from the Nordic lands and are interrelated. I’m Dutch by blood (my mum back 6 gens) but if you go back farther🤷‍♀️I may be Viking as they conquered certain areas etc. As far as female 🤷‍♀️I guess we all want to know what’s up with that?!

D🏃🏽‍♀️

[041051 in reply to Lgw19sof]

I have DD too and I'm female. My son has genetic haemochromatosis which is often called the "Celtic" disease.

[bethmoggie]

I have both, autoimmune connections maybe. Keeping my hands active seems to help and using a massage pad. I'm hoping to avoid contracting. Take good care, especially with the PA, dreadful condition.

[Laura1961]

I have PA and also had Depuytrens contracture a few years ago. my little finger bent in flat to my palm. I had to have surgery and although it is a lot better, it still in not straight. I have thick lumps in my palm also. So far it has only affected one hand.

[TSH110 in reply to Laura1961]

3 close relatives and one cousin had/have it, all just in one hand so hopefully it won’t start aflicting your other hand. I think I’m developing it, was not happy with consultant who said there’s no evidence - only a huge lump in my palm and all my fingers contracting into my palm esp the pinkie, it’s painful all the time abs is not functioning properly, there’s a lump in my foot in keeping with ledderhose disease and all those close family members with it - I have asked for a second opinion. It felt just like thyroid disease all over again - oh no all your thyroid disorder like symptoms are nothing to do with the thyroid....again and again until I was so ill with it I demanded a thyroid function test hyperthyroid one week extremely overtly hypothyroid a few weeks later almost dead a week after that! Not my thyroid my backside. There’s a lot of thyroid disorder in the family too, that was completely dismissed. I assume the two conditions are somehow related.

[Sleepybunny in reply to TSH110]

Link about ledderhose disease for those reading this thread.

dupuytrens-society.org.uk/i...

[ClaireCollymore]

Hello. I’m sure too sure if there is a medical connection but I have had PA for about 15 years and a few months ago I was diagnosed with dupuytrens contracture. I was also wondering if there is a connection between the two.

[MariLiz]

A very interesting question. I have lumpy looking tendons in my palms, that might be the start of Dupuytren’s . My husband has quite bad looking tendons in his hands, but so far hasn’t needed surgery. I am diagnosed with PA, he hasn’t had a blood test for low B12, but does have a diagnosis of CLL. We will investigate further.

[Dexy123]

This is very interesting. My grandma had dupuytrens contracture and my dad has it. Given that it is a dominant trait, i was of the understanding that I would develop it later in life (I’m 37 y o) but actually as it seems to be x-linked it makes sense that women are less commonly affected due to having 2 X chromosomes rather than the XY combination. I think neither of my two aunties have it the contracture but myself and one of my aunties have had b12 deficiency.

[G_Jones]

My Dupuytrens started over 20 years ago - very gradual progression - and was dreading any surgery that may have been needed - It resolved itself when I fell off a ladder and saved myself with the palm of my hand - which "mostly" corrected it - was not particularly painful either...

Hard to say when my B12 symptoms started - first thing I noticed (that I paid any attention to) was constant "yawning" - and excessive sleeping / tiredness - many other varying symptoms - to shorten a long story - after visiting my GP several times (& being criticised for visiting "Dr Google") I was sent away from my GP with an NHS website printout explaining "SAD" - and told I don't have B12 or PA problem because my blood test said (300 ish I think at the time)

I still feel rubbish most of the time - but take lots of high dose B12 tablets - which do seem to allow me to function.

Sorry for the thread hijack - the mention of Dupuytrens caught my eye !