I started 1000 mcg injections a week ago. I’ve had 5 injections so far but have felt worse than before injections. B12 levels were at 250 before injections and have been this same level for years. I have pretty much all symptoms of low b12 and have for years without knowing that my level is low since the US goes by a range of 200-950. UK goes by 500-950. The US range is disappointing. I plan on finishing last 2 doses this week but decided to take a few days off due to feeling awful. I expected an immediate improvement but after reading posts, it seems it will take a bit before alleviation of symptoms. I also plan to get folate and vitamin d checked next.
How long did it take you guys to feel positive improvements to symptoms? So far my symptoms have worsened since injections and have been having stomach issues as well.
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I got worse before better on the first 6 loading In jections. I had neurological symptoms. I saw improvements when every other day were reinstated 5 weeks later so by injection ? 14.
It's a roller coaster.
Improvements do happen. I'm in the UK so have hydrox b12.
When my b12 was tested the range was 200-900 pg/ml
Keep a diary.
List your symptoms
Rule out anything else
Yes good idea to get folate vitamin d and iron and ferritin tested.
I was told I'd be skipping down the road by Gp when loading finished !! I couldnt walk let alone skip
Have you thought of looking into ways of supporting your mitochondria. Heart, brain, liver are organs that use massive amounts of energy and so the cells in these organs have thousands of mitochondria in each cell. Other cells in the body have a few hundred less Mitochondria produce ATP the energy for the cell so that it can function.
We need to keep the numbers of out mitochondria up and we need to keep them healthy or we just won't be healthy
Simply said science has recently discovered also that mitochondria do not only make our energy (which they do from the nutrients you provide in your diet and light) But also they are sensitive to perceiving threat/danger from their environment which is your body at a cellular level. From chemicals, lack of nutrients so deficiencies like B12, stress, heavy metals, infection, negative thoughts, etc
When they detect all is safe, they produce ATP
When they feel threat, they switch off energy production and switch into defence mode enabling resources to focus on defence pathways until all is well again. The cell/body has only so many resources, so prority is key. This is known as the Cell Danger Response.
Theoretically the problem is that the mitochondria can get stuck in cell danger response and therefore aren't in energy producing mode. (even if the threat has been eradicated and well gone)
Symptoms would be any of the fatigue syndromes. And basically anything, because when the cell is not working optimally because it has little energy to function well then nothing works as it should. This includes immune function, nervous system signalling, mitochondria to microbiome organism messaging and gene signalling /epigenetics as well.
Should your immune system really be allowing long standing fungal infection.
Our mitochondria numbers naturally decline with age, and when there are too few, our cells don't have the energy to work and we die.
But we can support and increase their reproduction/ numbers and develop strong rather than live with weak mitochondria.
Key is: pay attention to circadian rhythms, sleep, nutrition, exercise /movement (not exhausting the system) intermittent fasting, being mindful of our thoughts/feeling safe
See Ari Whitten's website The Energy Blueprint. You can look into his book on Amazon about Red light and Near infrared light (to increase numbers of and create healthy mitochondria and healing)
Google Nicki Gratrix The Cell Danger Response and our Vagus Nerve Stimulation
Google Datis Karrazian and Vagus Nerve Simulation - crucial for nervous system messaging to prevent constipation. The Vagus Nerve running from the brain stem to the organs and body controls motility
Look up neurologist and researcher Dr Norman Doidge and his work with patients with Parkinsons, Fatigue Syndromes. Curing in a few weeks with Vagus Nerve Stimulation which stimulates mitochondria out of Dorsal mode (defence mode) into energy producing mode, using a tongue stimulator - early trials. But companies are already making electronic Tongue stimulating devices - not recommended at this early stage.
I am just listing the above incase you haven't heard of the link with mitochondria and our health to avoid criticism of WooWoo
We are all one body, everything impacts on everything else. We need to take a step backwards and back further to find the ultimate cause x
After looking a little more looks like the articles are using pmol/l and pg/ml interchangeably which is incorrect. Meaning japans range would be more like 135pg/ml on the lower range.
it is fairly common to feel worse before you feel better. I did but it improved with more injections. It took me many many months of daily injections but i have had Lyme disease in the past and i think this is why it took me so long to improve. Stick with it. it is not uncommon to experience new symptoms as the body floods with B12 so do not panic if this happens. Also keep an eye on your potassium levels as it can be used us as the body uptakes the B12. the best of love and luck on your journey to healing. x
My impression from reading many people stories is that it can definitely get worse before getting better and that it can take some time off regular injection before healing accumulates sufficiently - it seems to vary a lot between people. The reason seems to be that the B12 starts to stimulate nerve growth and processes in the body that have been deteriorating. Make sure you are eating well, resting, taking folic acid and b vitamins generally (altho limit B6).
Your body is building new blood cells in the first few months so needs iron - gentle form of iron supplementation is Spatone.
B6 excess can cause problems similar to B12d. I’m not sure of details but it is consistently advised to not have too much. I’ve read a paper on it but don’t have the link handy. Most B12 forums have this research.
Thanks Imogenta. I’ve been taking 100 mg of time to release vitamin B6 every other day which doesn’t seem like too much but I’ll cut it down if it’s going to work against my B12 therapy!
I want to suggest another really great iron supplement which is Douglas Laboratories ‘Feronyl’. It’s very well absorbed and easy on your gut.
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Mitochondria produce ATP the energy for the cell so that it can function. 
The cause of my B12 deficiency. 
Teenager with B12 Deficiency - Help
\"Function B12 Deficiency\" 
B12 deficiency...Super Confusing :(
