My English GP received my blood test results from St Thomas' hospital. The active b12 and MMA indicate " functional b12 deficiency at tissue level. "
I actually live in Spain and paid for these tests privately as the active b12 is not available here at all.
I have numerous, and now quite debilitating symptoms including neurological involvement. Probably started around 6 years ago, steadily getting worse until Oct 2014 when all symptoms got a lot worse. My Total Serum the past few years had been within" normal" range at 434. My GP here in spain had actually started me on 2 weekly jabs in Nov due to my worsening symptoms as a sort of trial. I had had one jab prior to the active b12 test which till showed low. I have since had a further 4 jabs with not much change in symptoms. After the last jab I had a bit less fatigue/weakness and achiness for a couple of days only. I do seem to have stopped losing weight though for the first time in 12 months and my appetite is better.
I see my GP for a review anyway next week as the prescription has run out. I will take my lab report with me and try and explain about the active b12 test and MMA.
Does anyone have experience of "Functional b12 deficiency" (the NHS website says it is where the proteins aren't transporting the b12 to the cells) and what treatment should I be hoping for? I'm guessing that I need more frequent injections than every 2 weeks......
Any comments appreciated. Thanks.