PA???

[Jan87]

I had a MMA blood test to check my B12 levels this was in January 2019, I was using a B12 spray then for energy as I have ME and fibromyalgia but came off the spray two weeks before I had the MMA blood test so would my result be skewed as it showed no deficiency of B12 when I was off the B12 spray those couple of weeks.

[Gambit62 Administrator]

recommendation is refraining from B12 supplementation 3-6 months before serum, active (holo-T), MMA and homocysteine tests.

It is likely that the tests will be skewed in terms of identifying an underlying absorption problem as a result of the supplementation.

[Jan87 in reply to Gambit62]

Oh ok so MMA test not right then?

[Gambit62 Administrator in reply to Jan87]

if the MMA comes back okay that means that your cells have enough B12 to run the process that recycles the MMA into a useful building block.

It doesn't tell you anything about how the B12 got there.

[Jan87 in reply to Gambit62]

Oh right I see, any idea how the B12 would get there then?

What is normal level for B12 or everyone different?

[Gambit62 Administrator in reply to Jan87]

normal range is where 90% of people are okay - there is no way of knowing exactly what the right point is you.

B12 gets into your cells by a) getting into your blood and b) being transferred from your blood to your cells. it is also possible that cells can vary in the efficiency with which they run processes that need B12.

MMA tells you how efficiently a process is running. If you don't have enough B12 it comes back high but as a test that is all it tells you.

[fbirder]

If the spray is getting enough B12 into your body to keep MMA low then keep using the spray. Unless it isn't helping with the symptoms - which suggests they're not caused by B12.

[Hanneke12 in reply to fbirder]

What would you consider low MMA, fbirder ? After using high dosage sublingual B12 for several months after booster injections, getting a serum level B12 of 1256 and MMA of 0,26, obviously B12 is absorbed into the blood (so no PA)... but: would you consider that a sufficiently high MMA level to suspect another absorption problem?

(Some context: I find myself at a loss without B12 injections, have many neurological symptoms, as do my dad and 34 year old brother..).

[Jan87 in reply to fbirder]

I have been off the spray awhile as wanting another B12 blood test, the tinnitus has got so much worse since October and doc says nothing I can do but doubt know if it’s B12 or not.

My symptoms on the spray wasn’t as bad as now.