I thought I would summarise the role of B12 and folate in the conversion of homocysteine to methionine.
As you can see in the diagram, methylcobalamin plays no special role. It, like other forms of B12, is converted to cob(II)alamin as soon as it enters the cell. For this reaction the cob(II)alamin is further reduced to cob(I)alamin. It is this that binds with the enzyme =,
A molecule of methylfolate and a molecule of homocysteine also bind with the enzyme. A methyl group is passed from the methylfolate to the cob(I)alamin which then passes it on to the homocysteine, converting it into methionine.
So methylcobalamin is formed, but fleetingly.
It should also be clear that taking methylcobalamin if you have a faulty MTHFR enzyme would be pointless.
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fbirder
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Thanks for that fbirder . I can’t say that I understand it all , but I’ve printed it out and will give it great attention . I had my homocysteine tested before I started self-injecting B12 (Hydroxocobalamin ) and supplementing with folic acid , and it was 15 . After a few months of weekly injections I was pleased to see it was 7 .Unfortunately an expensive test , so I won’t be doing it again in a hurry .
Want to say that when I told my doctor about the two results , she said it was no use telling her , as she knew nothing about homocysteine readings . I couldn’t believe it .
Thanks fbirder . Fairly new post so will leave open for a week (ish) then turn off replying ...or else you'll be responding to replies for, well...possibly decades 😳.
There are lots of other biochemical reaction that will remove methyl groups. I suspect it will initially be removed as methanol which would then get further oxidised to formate and then to carbon dioxide. CH3-O-H -> O=CH-O-H -> O=C=O
Methanol is fairly common in the human body. It’s only dangerous in very high amounts (grams rather than micrograms). Here’s some info researchgate.net/post/What_...
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