Trying Different B12 Types - Pernicious Anaemi...

Pernicious Anaemia Society

32,672 members24,065 posts

Trying Different B12 Types

DogInTheDisco profile image
9 Replies

Hiya,

I've been sub cut injecting with 1ml of 1500ug hydrox every 2 days for 2 1/2 weeks.

I think after feeling worse in some regards i've felt an improvement in my energy levels, but certainly not the drastic improvement some people report.

I know it takes a while for some people to see big improvements, and it depends how much damage has been done. But I need to make another order from versandapo and am wondering if I should try another kind of B12 (maybe cyano?) or if I haven't really given the hydrox enough of a chance?

I know it's different for everyone so no definitive answer can be given, but any opinions would be very very helpful as i'm in this on my own.

Thank you! xo

Written by
DogInTheDisco profile image
DogInTheDisco
To view profiles and participate in discussions please or .
Read more about...
9 Replies
fbirder profile image
fbirder

I would stick with the hydroxocobalamin. It’s generally recognised to the the best formulation. Both cyanocobalamin and hydroxocobalamin are converted to cobal(II)amin when they enter the cell - as do other forms. So they are all identical from that point onwards.

Tnwo and a half weeks is definitely not enough time for drastic improvements. If you had anaemia caused by the B12 deficiency then it takes longer than that to get your red cells back to normal.

Personally, I would cut the injections down to once a week, keep it at that for a month and see how things go. If you still have symptoms then go back to three a week. But if that does nothing after another month then I’d start looking at other causes.

DogInTheDisco profile image
DogInTheDisco in reply tofbirder

Can i ask why you'd cut it down to once a week? I've read that there isn't a downside to injecting 'too much' as your body just urinates the excess

I recently left around 4 days in between injections, and on the 4th day I felt the same extreme lethargy that i did daily before i started injecting - I haven't experienced that feeling whilst injecting once every 2 days

fbirder profile image
fbirder in reply toDogInTheDisco

I suggested once a week to see if it made any difference. You’ve obviously already tried that and found that it does.

designer8 profile image
designer8

Hi there - I know there are a lot of members who sub inject, and there are reports about there being no overall difference, other than the time it takes for the injections to work, and I have been subcutaneously injecting for some time, other than the odd IM injections by the doctor nurse. However, recently, my GP had me go off the injections to test for PA (don't ask :) ). On returning to my usual subcutaneous injections, I found they weren't working as they had previously. It wasn't until I went to the GP last week and we were talking about the injections not working, she realised I'd been doing them subcutaneously, rather than IM. She was adamant IM was better. She gave me an IM injection, and from then on I've been doing IM injections this week. I can only say that, from my experience this past week, compared to six weeks of subcutaneous injections (and I did a lot of them), that I feel much better. Not 100% but close enough too. Even when I went to buy the bigger needles (3ml, 23g, 1 1/14'') from the pharmacist yesterday, he said IM is the only way to go - not subcutaneous. Just my experience - hope this information helps you.

DogInTheDisco profile image
DogInTheDisco in reply todesigner8

Noooo, i've only just got used to doing sub cut myself!! Haha oh gosh... the thought of doing IM myself makes me feel sick and my doctors won't give me injections. Okay, I'm off to watch some tutorial vids on how to IM and hopefully feel less repulsed by it! Thank you so much for sharing! xo

fbirder profile image
fbirder in reply toDogInTheDisco

Subcutaneous should be just as good as intramuscular. After all, the B12 has to go somewhere once you put it in.

designer8 profile image
designer8

You're amazing!!! I don't do either myself - my husband does them. I actually found the IM don't hurt as much. If you're doing them yourself, the mid-outer thigh is still the best place, or if you're having someone else, do the deltoid (upper arm). This might help:

healthline.com/health/intra...

If you can do subcutaneous, you can do IM. Hope you feel better soon x

fbirder profile image
fbirder in reply todesigner8

They say that absorption is faster from intramuscular than subcutaneous. That’s not always the case.

And with B12 a slow absorption is better. That’s why some researchers are looking at developing slow-release formulations (there was a presentation at the PAS conference about this - on their website if you’re a member).

Ctadds1 profile image
Ctadds1

I know this post is quite old but I am wondering how you are doing in your healing. Did the B12 end up helping you?

Not what you're looking for?

You may also like...

Different Types of Methyl B12?

I have had PA for years and have been able to control it with Methyl injections.  The Federal Drug...
toddn661 profile image

Subcutaneous B12 Injections - what size needle?

I am going to start going sub cut injections with Hydrox. I've done intramuscular injections twice...
sami0x profile image

How long before B12 starts repairing damage?

I only ask as I know I've read somewhere that it can take up to 6 months before any real change is...
DaveT81 profile image

B12 doses

Hi, I'm after some advice I've not been here for a while and this is the only place I find people...
Green4me profile image

Different types of injections

Long story short my im having a hard time setting an appointment with neurologist. The drs office...
texans2002 profile image

Moderation team

See all
Gambit62 profile image
Gambit62Administrator
Foggyme profile image
FoggymeAdministrator
taka profile image
takaAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.