Negative Intrinsic Factor & Parietal ... - Pernicious Anaemi...

Pernicious Anaemia Society

32,623 members23,984 posts

Negative Intrinsic Factor & Parietal Cells

Eoperez profile image
6 Replies

Sorry for yet another post! Just found out that the parietal cells blood test that I was waiting for and thought would get me the treatment and recognition from the GP I needed has also come back negative.

As both now negative does this mean I do not have pernicious anaemia?

I'll probably have a phone consultation with GP on Monday but don't know where to go from here.

My b12 was 172 on 11 October. Found out last week that 10 years ago it was 140 odd (not sure if relevant or not). Ferritin and folate just in range. Thyroid well treated with 175mcg Levothyroxine.

Thanks in advance.

Written by
Eoperez profile image
Eoperez
To view profiles and participate in discussions please or .
Read more about...
6 Replies
fbirder profile image
fbirder

This is what the NICE guidelines say...

If anti-parietal cell antibody is not present it is unlikely that the person has pernicious anaemia

Gambit62 profile image
Gambit62Administrator

Eoperez, as fbirder says - the negative of GPCA does make it unlikely that the cause of your deficiency is PA - but there are a lot of other B12 absorption problems that can lead to B12 deficiency and very few of them are actually treatable.

If your thyroid problem is auto-immune then it may be worth sharing this article with your GP

ncbi.nlm.nih.gov/pmc/articl...

Eoperez profile image
Eoperez in reply toGambit62

Thanks both.

Guess my battle is now going to be trying to find out why B12 is low. Somebody mentioned coeliac disease & h pylori in another post so may be worth asking GP about them also :( just feel like I'm in a never ending battle with doctors at the mo!

JMN2017 profile image
JMN2017

Eoperez

There are some medications that can affect absorption so may be worth checking any medications you are taking to see if there is an increased chance of meds being the cause.

In particular, Metformin, PPIs - such as Omeperazole/Lansoperazol/Ranitidine/Cimetidine, are commonly prescribed meds which can affect absorption. I believe HRT/ Pill can affect this too. There are too many to mention here but if you put 'med' and 'B12' into Google, you should get a list of links to check through. Do this with each of your medication.

Hope this helps

J

Eoperez profile image
Eoperez in reply toJMN2017

Thanks. The only medication I'm on now is Levothyroxine. I did take Metformin for a few years (for PCOS) but stopped when i fell pregnant in 2015.

Marz profile image
Marz in reply toEoperez

ncbi.nlm.nih.gov/pmc/articl...

The above is one of many research papers discussing Low B12 - scroll down for the information regarding Metformin and B12 - for your GP :-)

There are many many more papers to be found ....

Not what you're looking for?

You may also like...

Intrinsic Factor and Gastric Parietal Cells Negative

Hi folks, Any advice would be much appreciated. I have today had my tests for IF and Gastric...
AmyG6500 profile image

Intrinsic Factor Negative

I’ve been feeling grotty for a couple of years and have thyroid antibodies. Started on...

homocysteine, intrinsic factor and Parietal cell antibody tests results?

Hi, I have been reading other posts and now have received my fathers results for the B12 followup...
jbthyro profile image

16 year old b12 135, negative intrinsic factor

My 16 year old son had been experiencing dizziness, headaches, low energy and tiredness for the...
Redazzy profile image

Intrinsic factor antibody

I'm posting on here as I been advised to. I've just been back to my GP because I had a blood test...
suzybear profile image

Moderation team

See all
Gambit62 profile image
Gambit62Administrator
Foggyme profile image
FoggymeAdministrator
taka profile image
takaAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.