Hello All. My GP recently prescribed a course of Ranitidine (histamine H2 receptor antagonist) for multiple duodenal ulcers / gastritis / duodenitis.
Prior to taking the tablets I read the patient information leaflet and it said to check with a pharmacist if there were problems with the immune system. Having had a recent positive ANA test (currently being investigated) I queried this with a pharmacist, who stated that she had never heard of this contraindication (despite it being on the PIL), that they were well tolerated, and to go ahead and take them.
Within four days I became very ill with greatly increased shortness of breath and muscle / joint pain. More worryingly, my throat, tongue and lips became completely numb, I had increased difficulty in swallowing and my rubber legs turned to jelly legs and, on occasion, I just could not make them 'go'. On the whole, I felt very ill indeed 😖.
I stopped taking the tablets! Since then the exacerbated symptoms have reduced, although not quite to my normal level of dysfunction.
Just wondering if any body else has had similar trouble with Ranitidine.
Also thought I might flag it up since the contraindication in immune conditions is not recorded in the British National Formulary (BNF) or other websites (although I did find a short mention on WebMD). I'm also not sure if immune conditions also covers autoimmune conditions?
If Ranitidine can cause problems to those with auto / immune problems, there might be others out there who are at risk of exacerbating symptoms without knowing (since pharmacists and doctors appear to be largely unaware of the potential problems).
I haven't been able to find any further information about what the impact might be on those with immune (or autoimmune?) conditions and would be very interested to hear if anybody out there knows what might have been going on.
P.s. - haven't included the problems of giving with low or no stomach acid or the impact on B12 uptake, but know these also exist.