Thiamine and headache?

[Ep0522]

What does it mean if I started.B1 100 mg and it gives me tremendous headache? Should I reduce further or could it mean I just can’t tolerate?

[rescuema]

I experienced the same and the headache lasted for about 5 days but It eventually went away. Dr. Derrick Lonsdale calls it a paradoxical healing reaction. As long as you experience these symptoms with the B1 (but not with pharma drugs), you stay on it until the symptoms go away and then titrate up the dosage, or if unbearable, you can lower the dosage to alleviate the symptom for a while and then later try to up the dosage slowly depending on the need. Also be sure you’re taking magnesium, a required co-factor.

[Ep0522 in reply to rescuema]

Thanks so much!

[rescuema in reply to Ep0522]

You should feel glad to experience the headache (I sure did) - it means your brain is trying to heal and you’re a b1 responder. 😉

[Fed1000 in reply to rescuema]

Hi rescuema, in your opinion what are the obvious symptoms that can be caused an overdose of B1?

[rescuema in reply to Fed1000]

B1 (esp B1 hcl, TTFD, etc) is safe and your body should excrete the excess vitamin through urine. However, if you experience back and leg pain or other unusual symptoms that don't ease up after a week or more, it will be a sign to cut back and be careful not to get deficient with other B vitamins. Adding a good B complex as well as a good multi (for the needed trace minerals) is a good idea. The one thing I would strongly caution against is not to overdose on folate, especially if you're an undermethylator (genetic or epigenetic) because it can affect the serotonin activity for the worse for people with neurotransmitter issues.

[MarionP in reply to rescuema]

Sorry can you put words to the acronym TTFD please?

[Gioc in reply to MarionP]

I quote “

“A class of synthetic disulfide and S-acyl thiamine derivatives, for example, benfotiamine (S-benzoylthiamine O-monophosphate), thiamine tetrahydrofurfuryl disulfide (TTFD), and sulbutiamine (isobutyryl thiamine disulfide), with varying TPP+ pharmacokinetic and safety profiles, have also been developed based upon the molecular structure of allithiamine.”

sciencedirect.com/topics/me...

[MarionP in reply to Gioc]

Thanks. Sorry I asked.

No, seriously, since I think benfotiamine might just be fat soluble, whereas thiamine HCL is water soluble, meaning the latter will not build up in fat tissue, rather than flush back out) and without checking my basic chemistry some of these others look like they might also be fat soluble) it's important for people to know if these apples are not oranges. At high levels, fat soluble preparations of B1 can build up to be possibly toxic. Might make a difference. Thus I suspect a little more clarity on these might be needed. I sure wouldn't mind some. And so far, Dr. C's work does is about thiamine HCL only, which is pretty safe because whatever you don't use leaves your body quickly. You might have an allergy or flushing or BP reaction, but except for allergy to something in the specific manufacturer's version, those resolve with adjusting the dose.

I see Esther51 has not said which type of B1 she was using.

[Ep0522 in reply to MarionP]

It was a sublingual of source naturals, and I believe it said on the bottle coenzymated b1 - 100 mg.

[MarionP in reply to Ep0522]

Good luck with that, doesn't tell one very much, will take someone better informed than me...and of course, you don't know exactly what all the ingredients are, being non-pharmaceutical. Without knowing more, I would at least want to switch to something that says "thiamine HCL."

Of course, if you have the means and willingness, the absolute gold standard for getting what you want and think you are getting without anything else to also cause problems is is the expensive, doctor prescription-required injected pharmaceutical. Also, what rescuema says below.

[rescuema in reply to Ep0522]

That's an active form that bypasses the cofactors for thiamine conversion. Not a lot of anecdotal reports pertaining to PD, but there shouldn't be much difference biological activity wise once absorbed into the brain. One thing does come to my mind - be sure you're not deficient in choline - some people have genetic mutations that cause choline wasting during methylation pathways, and the deficiency can cause migraine/headaches. If Choline doesn't help, look into Citicoline. Try a few raw egg yolks for starters.

lpi.oregonstate.edu/mic/oth...

[rescuema in reply to MarionP]

TTFD (thiamine tetrahydrofurfuryl disulfide) aka Allithiamine/Lipothiamine is distinctly different from the fat soluble Benfotiamine (S-benzoylthiamine O-monophosphate). TTFD directly crosses the BBB without requiring the enzyme transporters and ideal for individuals with compromised genetics or deficient transketolase activity. Although it can pass the lipid barrier, it is in fact water soluble and can be given intravenously.

[MarionP in reply to rescuema]

TY

[pvw2]

Symptoms of Vitamin B1 toxicity

rightdiagnosis.com/v/vitami...

[Phxrsng]

This won’t help 2 years later but I myself had a visceral reaction. I have a host of health issues and am used to these types of reactions but I took 50mgs hcl from seeking health. There are no other additives in it. Day one I took a half pill and felt sleepy and odd. Day 2 I took a whole pill and felt a bit of a headache coming on that worsened through the next day. I also felt very weepy and anxious. When I took the third pill on day 3 I got whacked with a terrible migraine. But this wasn’t a normal migraine. It was like I felt things happening in my brain. Like sensations on top of all the pain and the migraine was just throbbing. My pulse felt very High and the headache was through my whole head neck and sinuses but it felt like something was stabbing through my head. This wasn’t what I was used to. My hands and feet also hurt. Which is something I deal with. I have beriberi and it’s likely gone undiagnosed for a long time. I had expected to feel better. It exhausts me and after the episode I had it wouldn’t stay down. But my body also vomited it out really violently. It felt like my stomach was in literal spasm and there was a lot of pain. I’m wondering if it’s the hcl variant. I’m at a loss but maybe this will help someone. I also have cbs mutation so sulphur donors are a problem which is why the other types weren’t an option.

[chartist in reply to Phxrsng]

Dr. Costantini reported one female office patient who each time she would take her B1 injection would throw up almost immediately and consequently was not able to use thiamine.

Art