Parkinson's Movement

This gut/brain axis paper offers food therapies

Section 5.1. discusses food intervention.

It’s a long paper and while much of it is above my pay grade, I thought it a good paper and more heavily referenced than any other I’ve read. It doesn’t talk about lectins, but Dr. Grundy does.

I’ve read his book, The Plant Paradox, and he makes a compelling case, but like a lot of researchers who get totally focused on one thing, to him, lectins are the source of all evil. His explanation that they cause leaky gut seem totally plausible, though and in response, my wife and I have cut our lectin consumption down by 90%. (I’ve stopped trying for 100% of anything. The extra lift between 90% and 100% is just not worth it and 90% is always good enough.)

Here is an interview of Dr. Grundy by Joseph Cohen (who I follow,) author of SelfHacked, an excellent nutrition researcher.

I think one of the important things about the gut/brain connection is that the health of our gut is something that we have a lot of control over.

Here are a few sample sentence fragments gut/brain axis paper.

“Probiotics are specific microorganisms that when administered in adequate amounts can exert a health benefit on the host by restoring microbiota and maintaining immune homeostasis.”

“The most common probiotic bacteria currently used are representatives of Lactobacilli, Enterococci, Bifidobacteria, yeasts and mixtures of different beneficial bacteria. … Lactobacillus reuteri supplementation improved bowel movement frequency in adults with chronic functional constipations …The administration of Lactobacillus casei strain Shirota in chronic fatigue syndrome patients significantly decreased anxiety symptoms … the administration of Bacteroides fragilis reversed the abnormalities in gut permeability …”

“Probiotics might be a powerful tool in order to alter PD-associated microbiota composition and improve GI function and therefore reduce gut leakiness, bacterial translocation and the associated neuro-inflammation in the ENS.”

“Improving GI function by supplementation with probiotics might … also improve levodopa absorption and reduce behavioral and cognitive deficits such as anxiety, depression and memory problems which are common in PD patients.”

“… studies have shown that is possible to modulate brain function by improving anxiety and depression using probiotics. …

“Prebiotic fibers have been shown to have beneficial effects on immune function, bowel motility and constipation that might be very relevant for inflammation and GI-related symptoms in PD.”

… cofactors … such as B-vitamins, vitamin C, vitamin E and selenium can increase the availability of … membrane precursors by enhancing precursors uptake and metabolism.

The preventive dietary intervention was not only effective for the mitochondrial dysfunction induced motor symptoms but also reduced alpha-synuclein accumulation and inflammation in the colon …


1 Reply

Nice post MBA.


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