Which pill for Parkinson's disease provides the fastest relief from "off" symptoms when chewed and swallowed: carbidopa-levodopa 25-100 mg Orally Dissolving Tablets, or ropinirole Immediate Release, or pramipexole Immediate Release ?
It seems like the ODT (Orally Dissolving Tablet) form of carbidopa should work fast, but the levodopa requires conversion to dopamine in the brain, which takes time. Dopamine agonists can work immediately when they reach the brain, without any conversion required.
Anecdotal replies are solicited as well as links to PubMed abstracts or papers.