Significance of Newly Approved IPX203 for Parkinson Disease

[Farooqji]

Earlier this month, the FDA approved Amneal Pharmaceuticals’ investigational agent IPX203, an oral formulation of carbidopa/levodopa (CD/LD) extended-release capsules, as a treatment for patients with Parkinson disease (PD). Marketed as Crexont, the therapy is an oral formulation CD/LD which includes immediate-release granules as well as extended-release pellets. In its announcement, Amneal noted it expects the oral treatment to be available to patients in the United States in September 2024.

neurologylive.com/view/sign...

[Buckholt]

So now it’s about the cost. If people can’t afford it or if in the UK the cost benefit analysis means it cannot be universally prescribed, then ………..

[Smittybear7]

who would it be available to thanks for sharing

[Grey_Area]

I posted this info in another forum. The drug is also known as "Crexont".

What I can't find is what's so different about it compared to other controlled release L-Dopa products like Sinemet CR

Reading the info you'd be forgiven for thinking this was the first controlled release L-Dopa ever. In particular why have they benchmarked it against standard release rather than another CR product?

[JPeezy]

sounds just like Rytary

[rebtar]

Very strange. I searched for Crexont vs Rytary, an article apeared, i could see the furst paragraph, but i couldnt get access. When i tried a second time, instead of the article, it said "page doesn't exist".

[rebtar]

pdexpertinstitute.com/exten...

[Gioc in reply to rebtar]

In my opinion, these pellet medications always have a wide standard deviation (SD) that is not shown in the above graphs (figure 3; there should be vertical lines above each point). It would have been important to know this SD data in order to understand if the response to the medication is the same for everyone or subjective.

[rebtar in reply to Gioc]

👍

[Jmellano]

my neuro may consider switching me from Rytary to IPX203. He said the neuros need training on how to choose the right dosages and pricingt has to be provided. He thinks in my case, it may cut back on # times/ day IPX203 has to be taken. Currently, i take Rytary 4x/day

[Jmellano in reply to Jmellano]

It’s show time today.! Today is my first day on Crexont I am interested to see how effective

should be interesting to see how effective it is at nite for me.my uptimes are definitely are longer and it is great having to take pills only 3x per day.

You may have to have request that Crexont be added to the insurance company’s formulary.

Crexont is not cheap (what a surprise) my copay for a months supply was about$200, but I believe most of copay assistance companies will cover that.

the capsules are large and depending how my dysphagia is I may take with applesauce. I will update my experience going forward.

[Farooqji in reply to Jmellano]

Keep us updated

[Jmellano in reply to Farooqji]

Will do, I think before I decide to stay on this instead of rytary, I will give it a week to settle in

[Jmellano in reply to Jmellano]

Still on the med, will stay on it for a week before I make an assessment, no issues so far

[KOLACHKY in reply to Jmellano]

Can you share the dosage transition amounts from Rytary to Crexont?

[Jmellano in reply to KOLACHKY]

My Neuro had done it, not sure what he used for converting to Crexont, but I can tell you what daily amount I took of rytary and what he prescribed for Crexont

Rytary (5) 145s, (1) 99 taken in 5 doses

Crexont (6) 70/280 in 3 doses

I hope this helps. There are also websites that do some conversions

[KOLACHKY in reply to Jmellano]

Any updates on experience with Crexont?

[Jmellano in reply to KOLACHKY]

hi, i WILL MOST LIKELY REMAIN ON CREXONT SINCE I ONLY HAVE TO TAKE IT 3X/DAY VS, 5X DAY WITH RYTARY

[healthabc in reply to Jmellano]

Whats the Crexont update, if you don't mind sharing?

[dkdc]

ncbi.nlm.nih.gov/pmc/articl...

Rytary vs Crexont vs IR sinemet

[Jmellano]

I just resumed taking it, 7am,1pm and 7 pm. Don’t think change of Crexont to rytary was reason I felt like crap, more likely it is ptogression.