Help me re MAO-B inhibitors like "irreversible" Azilect

[BUZZ1397]

It is written that Azilect makes irreversible changes in the brain. "Rasagiline (Azilect, TVP-1012, N-propargyl-1(R)-aminoindan) is an irreversible inhibitor of monoamine oxidase-B". So the question is, why do we need to continue to take it? The effect was irreversible. Why isn't a few doses sufficient for a lifetime? I anticipate some will say things like, its so the manufacturer will make more money. Please...?

[BUZZ1397]

Hi HAL. I know this is stupid fun but I hope to learn something.

[BUZZ1397]

AHA! Well I am hoping for a simple answer and I suspect the answer giver need be a person gifted in translating the complex for the simple-minded.

[parkie13]

How did you find out it's irreversible? And what does it do to you? Mary

[BUZZ1397 in reply to parkie13]

askapatient.com/adverse-eve...

[BUZZ1397]

Reading the literature that comes with and it is also online. I would not be the one to ask what "irreversible MAO-B Oxidase inhibitor" means. That's why I posted the question darling. I was looking at some tables of adverse events caused by taking Azilect, events tracked by the FDA. It seems also that the right dose of Azilect is individual ized, as evidence the literature I read speaks to a U shaped graph when charting adverse events along with dose taken. I was told that means that sometimes too little causes problem ad other times too much causes problem. But also alarming is the number death and of hospitalizations linked to Azliect that have been reported, a number well over 2000 and that is "reported". Also the number of adverse events goes up with the age of the patient.

Types of Adverse Events for AZILECT

Total Reports Filed with FDA: 8588

DeathLife-threateningHospitalizationOtherUnknown07501,5002,2503,000# of Reports

Outcome Male Female Unknown

Death 267 134 16

Life-threatening 35 52 1

Hospitalization 1,510 1,183 99

Other 1,185 1,160 95

Unknown 1,513 1,236 102

Male Patients

Male

Female Patients

Female

Unknown Patients

Unknown

Total Reports Filed with FDA: 8588*

[parkie13]

I can't access askapatient.com. I get this it does not recognize my browser that is the only site that does it and before I could get on it . so I wonder if it's some kind of a malware that is trying to get in my cell phone.

But as I said that I thought I was losing my mind when I was on it for two and a half months.

[_Eureka]

it is irreversible but there is ongoing biosynthesis of mao-b in the brain

[BUZZ1397 in reply to _Eureka]

The production of molecules within the cells, biosynthesis. So, the enzyme production within our body's cells returns to normal, you believe? Is that a certainty?

[park_bear in reply to BUZZ1397]

All that irreversible means in this context is a molecule of Azilect binds irreversibly to a molecule of MAO-B. As eureka points out more is being made all the time.

[BUZZ1397 in reply to park_bear]

Oh yeah, continued administration makes sense now. Mr. Park-Bear you have demonstrated talent for explaining the complex to the simple-minded.

[park_bear in reply to BUZZ1397]

You are not the only one to have found this terminology confusing!

[_Eureka in reply to BUZZ1397]

sorry i didn't reply earlier (was busy with christmas preparations & celebrations) but i see park_bear has already answered the question.

[BUZZ1397 in reply to _Eureka]

Given individual variation in rate of biosynthesis, all that remains is to discover a way to determine that which seems to be fluid, individualized, hence undo-able except on accident, :(. The perfect dose for an individual patient to experience optimal efficacy is guessed at by molecular biologists who have tracked reports of hundreds of patients responses. Given that some toxicity is known to occur at the cellular level when more Azilect molecules than needed reach a cell and research has identified the path of toxicity but not determined the import of the Azilect toxicity, I choose to punt. Until more is known, I will stay in the game just reduce my Azilect Rx order to a half a mg dose, every other day. I'm chicken.

[_Eureka in reply to BUZZ1397]

i'm so chicken, i haven't even started any medication yet...

[paddyfield]

I believe its not a reversible ASDA ordinary man in the street might understand the word can't find the reference

[Catlou]

So we shouldn't take It? I'm on. Half pill for neuroprotective possibly

[ecurb]

Hi @Buzz 137, what you have revealed about Azilect is very disconcerting to say the least. I have been taking 1 mg per day for about 6 weeks now. After about a week I was suffering less from my major symptom which is extreme contraction of what I suppose is my diaphragm, which occurs every 3 hours or so and lasts about 2 hours during which I have to lie down to get relief. As I said Azilect seems to almost eliminate that symptom. But on the other hand other symptoms have become worse : poor balance, blurred vision, poor concentration and difficulty to find words when speaking, lightheadiness. fatigue and excessive sleepiness during the day... I have had most of these symptoms for some time but not as strong nor all together.

Does this condition sound familiar to anyone, especially if you have been through this stage and with time have felt Azilect is helping you.

[BUZZ1397 in reply to ecurb]

Wow, no I didn't mean to implore you to not take your Rx. I was just searching for understanding of what irreversible means within the product literature that comes with my Azilect Rx.

[Catlou in reply to ecurb]

Poor balance and blurred vision. I take a half pill. But I was put on it to extend my on time. Which isn't really happening

[movinngroovin]

It made me projectile vomit

[TheresaCurley]

It seems my eye sight is getting worse and my balance is poor, but I have no idea if it is the Azilect or not. I take 1mg a day. I had a really bad fall in the parking lot at the movies three days ago. I always land on my right side when I fall and it seems like my right side is forever bruised.

[BUZZ1397]

Oh no, you must be sore all over. Please be very careful.

[Beachwalker]

Good morning! I've been taking Azilect 1mg as Monotherapy for 20 months now. I was diagnosed in April 2015. I'm early stage with tremor and rigidity on my right side being my symptoms. I do extremely well on Azilect and will continue to take it until I no longer need it. I'm one of the fortunate ones that do get the relief benefits from Azilect.

BW

[BUZZ1397 in reply to Beachwalker]

Your individual need for it must fall right in the median of the patients they did patient response research on. Lucky fellow or gal, you are.

[LAJ12345]

healthunlocked.com/parkinso...

ncbi.nlm.nih.gov/pubmed/302...