Why we should be interested in natural MAO Inhibitors.

[SilentEchoes]

This is an interesting concept.

thesunlightexperiment.com/b...

[rescuema]

I use Zagarese Licorice drops whenever I need help raising [my low] blood pressure - they're also tasty treats and work quickly when kept under my tongue. I also drink organic Matcha (from Japan) daily - a much better version of green tea.

[Hidden in reply to rescuema]

Hi Rescuema - Does Zagarese licorice really help increase blood pressure? My blood is on the low side and I have orthostatic hypotension. Wonder if this can help that. And licorice is a natural moa inhibitor. Could be a double bonus.

[rescuema in reply to Hidden]

Yes, it helped me when nothing else would. My BP dropped precariously when I was eating too much cauliflower in my diet - totally anecdotal and no one else ever reports the issue, but I believe it may be oxalate related, so you may want to examine your diet as well. I also noticed ginseng also helps me, but I read some may experience an opposite result - lowers high BP, so its benefit may be adaptogenic.

I use Auragin in case you want to try since there are a lot of fake ginseng products out there. I use ginseng on top of Zagareses when needing extra help. I keep the round drops under the tongue as well, and these taste exactly like ginseng.

amazon.com/gp/product/B00JV...

[Hidden in reply to rescuema]

Just received the Zagrese licorice and took 3 nibs. How long does it take to raise blood pressure or alleviate orthostatic hypotension resuema?

[rescuema in reply to Hidden]

In my case, I noticed it right away, within 30 minutes of being done with the drops. I kept the drops under my tongue the whole time, so I'd say about an hour or so? Did you measure your BP before taking it and measure it again for a comparison?

[Hidden in reply to rescuema]

No I didn’t check BP but I will know when I stand up. Just tried standing up quickly and it seems to work! Hope it’s not a placebo effect. Do you take it multiple times a day?

[rescuema in reply to Hidden]

Sorry, I missed your response earlier while distracted. You want to monitor your BP while using licorice so that it doesn't shoot your BP dangerously high - this can happen easily, and you should also watch for potassium level so that it doesn't get too low. Get a BP monitor (I like Omron) if you don't have one. I haven't had a BP issue since correcting my diet but mostly used it before sleep. Good luck!

[park_bear]

This article makes the claim:

"Why We Need New MAO Inhibitors...The downside to MAO inhibition is the adverse side effects that often come along with their long term use [7]."

Yet the reference that is given to support this claim says nothing of the kind. There is a legal maxim applies here: Falsus in uno, falsus in omnibus.

[SilentEchoes in reply to park_bear]

That's a pretty broad paint brush you're using.

SE

[park_bear in reply to SilentEchoes]

You are right. I did paint with an overly broad brush. I do agree it is useful to be aware of natural MAO inhibitors for various reasons.

That said, I was offended to my core by an apparent lie about something of utmost importance. If prescription MAO-B inhibitors do have adverse effects that arise with long-term use it is of vital importance to those of us who use them to know what they are and under what conditions they arise. To falsely assert this idea as an excuse to write about natural versions is a bannable offense by this writer, in my opinion.

[rescuema]

Relevant articles to review.

"MAOIs prevent the break down of tyramine found in the body as well as certain foods, drinks, and other medications. Patients that take MAOIs and consume tyramine-containing foods or drinks will exhibit high serum tyramine level.[13][14] A high level of tyramine can cause a sudden increase in blood pressure, called the tyramine pressor response.[14] Even though it is rare, a high tyramine level can trigger a cerebral hemorrhage, which can even result in death."

ncbi.nlm.nih.gov/books/NBK5...

"Side effects of MAO-B inhibitors:

Each medication has its own set of possible side effects. Selegiline (found in Eldepryl, Carbex and Zelapar) may cause dizziness, headache, confusion, nausea, insomnia, dyskinesia (uncontrolled, abnormal movements), and agitation. Rasagiline (found in Azilect) may cause increased dyskinesias (uncontrolled, abnormal movements), orthostatic hypotension (falling blood pressure that occurs upon standing), headaches, joint pain, and indigestion."

parkinsonsdisease.net/medic...

[SilentEchoes in reply to rescuema]

True. If a person uses MAOIs they need to be aware of the dietary restrictions.

However, eating healthy fresh food isn't really a restriction. I believe the potential benefit of MAOIs outweighs the risks when appropriate lifestyle and dietary changes are made. This is why I presented the information for people to consider and decide for themselves.

SE

*Edit. The side effects you cite are for pharmaceutical drugs. The article I referenced lists naturally occurring MAOIs from supplements. I think we can all agree that naturally occurring dopamine from mucuna pruriens is not the same as synthetic levodopa/carbidopa, even though they both boost dopamine levels. This is the same principle for naturally occurring MAOIs vs drugs like selegiline.

[rescuema in reply to SilentEchoes]

"The side effects you cite are for pharmaceutical drugs." - yes, the myriad adverse side effects.

I agree and prefer the natural route whenever possible. Besides, I love my daily tasty matcha but even that I need to be careful not to go over 2 cups.

😉

[Hidden in reply to rescuema]

I have been reading more about this. But the adverse affects of tyramine rich foods are associated with MAOIs and not MAOB? I am on Azilect. I have recently had multiple episodes of my pulse throbbing in my head. And my husband could feel my pulse while holding my hand. I felt like my head was bouncing on the pillow and I could hear my pulse in my ears. I was petrified. I thought I was bringing this in myself with an anxiety attack. But now I’m thinking tyramine rich foods while on Azilect? I occasionally use brewers yeast, eat aged and raw milk cheese (thought it was healthier) and eat fermented food. So was I responding to too much tyramine even though it’s an MAOB not MAOI? I HATE that I’m on meds!!! I’m only 46!

[rescuema in reply to Hidden]

"AZILECT is contraindicated for use with meperidine, tramadol, methadone, propoxyphene, and MAO inhibitors (MAOIs), including other selective MAO-B inhibitors ...

Results of a tyramine challenge study indicate that rasagiline at recommended doses is relatively selective for inhibiting MAO-B and can be used without dietary tyramine restriction. However, certain foods (e.g., aged cheeses, such as Stilton cheese) may contain very high amounts of tyramine (i.e., 150 mg or greater) and could potentially cause severe hypertension caused by tyramine interaction in patients taking AZILECT due to mild increased sensitivity to tyramine at recommended doses. Relative selectivity of AZILECT for inhibiting MAO-B diminished in a dose-related manner as the dose progressively increased above the highest recommended daily dose (1 mg) ...

MAO in the gastrointestinal tract and liver (primarily type A) provides protection from exogenous amines (e.g., tyramine) that have the capacity, if absorbed intact, to cause a tyramine reaction with hypertension including clinical syndromes referred to as hypertensive urgency, crisis, or emergency. Foods and medications containing large amounts of exogenous amines (e.g., from fermented cheese, herring, over-the-counter cough/cold medications) may cause release of norepinephrine resulting in a rise in systemic blood pressure.

Results of a special tyramine challenge study indicate that rasagiline is selective for MAO-B at recommended doses and can be used without dietary tyramine restriction. However, certain foods may contain very high amounts (i.e., 150 mg or greater) of tyramine and could potentially cause a hypertensive reaction in individual patients taking AZILECT due to increased sensitivity to tyramine. Selectivity for inhibiting MAO-B diminishes in a dose-related manner as the dose is progressively increased above the recommended daily doses.

There were no cases of hypertensive crisis in the clinical development program associated with 1 mg daily AZILECT treatment, in which most patients did not follow dietary tyramine restriction.

There have been postmarketing reports of patients who experienced significantly elevated blood pressure (including rare cases of hypertensive crisis) after ingestion of unknown amounts of tyramine-rich foods while taking recommended doses of AZILECT. Patients should be advised to avoid foods containing a very large amount of tyramine while taking recommended doses of AZILECT [see WARNINGS AND PRECAUTIONS]."

rxlist.com/azilect-drug.htm

[Hidden in reply to rescuema]

“Over the counter cough and cold medicine.” Ambroxol? I miss my days of med free ignorance

[rescuema in reply to Hidden]

Also visit botanical-online.com/en/med...

Also you may have missed this precautionary thread of mixing natural MAOis with pharmaceuticals.

healthunlocked.com/cure-par...

[MarionP]

The sunlight article is nonsense.

[SilentEchoes in reply to MarionP]

Do what you please.

[MarionP in reply to SilentEchoes]

If you say so, thanks for the permission.

You know, you're not "Letting It Be."