Good news on recurrence

[Towergirl]

Hi Ladies

I’ve had good news from my July scan report. All new growth from recurrence is NED, good partial remission 😊

I had 6 cycles of Caelyx/Carbo after recurrence when 7 months of PARP Olaparib should have but hadn’t work, instead had new growth.

I also started Avastin privately with Lloyds home service. Had two before July scan after my March scan showed only slight reduction.

Worryingly, I’ve still got the original tumour above spleen reduced but still there!

. I’m HGS BRACA 2 had hoped for a trial . Anyone know of any open soon?

Oncologist said no to Glorioso trial, my samples from 2018 too old, a bit like me 🤣

Having a few more Avastin cycles , without a trial I will start hormone therapy for maintenance in October, which is the nhs pathway.

Confused as was ER negative in 2005 with breast cancer so needed chemo now ER positive for OC! Will hormone treatment let me down or be successful??

like all you lovely ladies it’s a rollercoaster journey but I’m still here and fighting the fight.

Best wishes to anyone have a great weekend.🌞

[Tealgirl7]

I don't know anything about the hormone treatment but go for it. You are a real trooper. I am on a trial now with avastin and parp. I am braca negative. My disease is stable. I have never been NED and was diagnosed stage 4 in 2006. Sending you good vibes

[bettycor in reply to Tealgirl7]

It’s great to hear that you’re stable after being diagnosed with stage 4 in 2006 and never being NED. You made my day. I was diagnosed with stage 4 in January of this year. I’ve had 9 chemo treatments, carbo & taxol with Avastin added for the last 2, trying to get my CA-125 below 1000 so that I can have surgery. CA-125 was 17,000 in February. Now 1500. It’s progress but slower than expected. Fortunately, I’m tolerating the chemo well. Have a great day!

[Tealgirl7 in reply to bettycor]

Wishing the best to you. I had a huge debulking surgery after a few chemos in 2006

[Star_22 in reply to Tealgirl7]

Interesting to read you are having Avastin even though BCRA negative. What is the parp? It’s always so good to read about those who are doing so well - thank you for sharing x

[Towergirl in reply to Star_22]

I was taking PARP inhibitor Olaparib, recommended for BRAC 2 positive for 7 months. These inhibitors hold down the protein which is known to feed the cancer.

CT scan results showed they hadn’t worked as did my raised CA 125. Had to go back on Chemotherapy

Paying privately for Avastin as not had before, worth trying as other than chemotherapy, hormone inhibitors for ER positive is the next step.

[Tealgirl7 in reply to Star_22]

Avastin is not dependent on the BRACA status. But instead of taking Olaparib I take Niraparib which is for people that are negative.

[Alfiepop]

Hello.

If your archival sample is too old to be tested it can be possible for a new one to be taken for testing to see if you are eligible to be considered for the GLORIOSA trial.

Insist on a referral, let The Marsden decide.

Best wishes to you

Lisa

[candyapplegrey in reply to Alfiepop]

What's the Gloriosa trial? I agree with you, Lisa, re sample. Can they not do a new one? Good luck anyway. xx

[Alfiepop in reply to candyapplegrey]

GLORIOSA: A study of Mirvetuximab Soravtansine and Bevacizumab as Maintenance therapy in Platinum-sensitive Ovarian Cancer

[candyapplegrey in reply to Alfiepop]

Thank you!

[Lirene]

Hi, if you google Gloriosa trial it will link to Target OC and it’s being carried out by Royal Marsden. Love and prayers Lx

[Towergirl in reply to Lirene]

Thank you Lirene for the interesting information linking Gloriosa trial to the Target trial. Last meeting my Oncologist mentioned the possibility of Target for me but not Gloriosa. He will discuss with me at Septembers meeting in more detail.

Brilliant news Target is nationwide with Christie’s involvement which is an hour away for me if I’m excepted. 😊

Best wishes to you xx

[Sk72]

Thank you for sharing - positive stories like yours give me hope.