First recurrence

[Driebergen]

Hello everyone,

In May 2022 I was diagnosed with high-grade serous carcinoma, Mullerian primary, Ovarian cancer. Had 6 chemo treatments and debulking surgery.

10 months after my last chemo, I am faced with a recurrence. Can you let me know what your treatment plan was after your first recurrence? My doctor wants 4 two weekly chemo treatments with Doxil, Avastin and Carbo

I am also wondering how many of you sought a second opinion and if that was helpful. I do trust my diagnosis and I do trust my doctor, but I am just wondering if, by seeking a second opinion, there might be a different treatment plan…

Thank you so much! And good luck to all of you brave ladies!!!

Judith

[Saintgermain]

Hello I’m facing my first recurrence was Ned 22 months starting chemo next week I’m in the states will be getting 6 rounds of Carbo/taxol like frontline but my Onc is adding keytruda an immunotherapy agent to the mix. I’m low grade so it will be every 3 weeks HG serous does have weekly infusions I think the Doxil, Avastin and Carbo is a mix that is used quite often but you can always get a second opinion I contacted Mayo and they agreed with my recurrence recommendation

[Driebergen in reply to Saintgermain]

Thank you so much for your reply! Good luck with your chemo next week❤️

[SGC2021]

Hi! Most of us know how emotionally tough the first recurrence feels. My heart understands. I got 12 months before it recurred. I did seek a second opinion who verified all that was being done. That helped me. I went on 6 sessions of doxil/taxol. It wasn’t as difficult as carbo. It took me back to NED. It’s chronic so we have to always watch for it. Good luck with your decisions and be healthy!

[Driebergen in reply to SGC2021]

Thank you so much for your reply. It is tough! The realization that this is chronic makes it so hard…

[SGC2021 in reply to Driebergen]

I know it does. I think though if we accept that it’s now a part of our life, we live each day fully and appreciate so much more about life.

[delia2]

Hi. I also had carbo and doxil (caelyx), but it was six cycles four weeks apart. I found it easier than frontline but mostly because of the four weeks in between. I then went on Olaparib for three years ( somatic brca1). You need to use lots of moisture r on hands and feet and avoid anything harsh in your mouth or on your skin.xx

[Driebergen in reply to delia2]

Thank you very much for your reply and for the tip to moisturize hands and feet!!

[Summergold2]

same as above doxil caelyx and Olaparib am not braca only had 4 months ned after but easier than carbo taxol my cancer is very aggressive so been on chem of some sort since 2019 still here though just not able to travel outside the us but hoping this Abraxane will be able to keep at bay all on liver

[grammeejill]

I recurred 5 years after treatment for stage 3B. Thought I beat it. I noticed a lump in my groin area and my onc had it biopsyed. Yup, it was back. He performed surgery to remove the lump and then I had 25 rounds of radiation. Seems ok now, 3 years later.

[NewtonEmma1900]

I am similar to 2 other replies. My first recurrence was carbo/caelyx and I am now on Niraparib. Good luck 🙏

[StilCrazy]

HiAfter the same treatment, mine recurred after 6 months but only in the abdominal lymph nodes.. Avastin and carbo were advised but no doxcil. I went on statins, metformin and fenbendazole for their anti cancer effect and did nothing more. It has been 6 months now and they are not growing yet. My oncologist has agreed to scan every 4 months and only intervene when the tumour size or position is life threatening. [edited by moderator]

[soyoonsoy]

I think second opinion is a good idea. I didn't have a good one, but my oncologist at the time wanted to repeat Carbo/paclitaxol, which revealed my tumor was platinum-resistant after 4 rounds. I think options are greater among new therapies if your tumor still platinum-sensitive. I don't know where you live, but in the US, there are many more clinical trials for P-S tumors. This early on, if your tumor is still localized, I would seek out all available clinical trials.