Avastin Gave Me Kidney Damage/Doxil Didn't Work

[Nancybib]

Hello Ladies,

Here is my story: First line treatment, I did amazing (or so I thought). My scans were clean and I lived a short remission. I recurred and was put on monthly doses of Avastin and Doxil. The Avastin has given me a terrible time. I had to stop after three full doses. I now have high blood pressure and kidney damage from the Avastin. My kidney levels keep rising although I have been off the Avastin for two months. The Avastin also created issues with my hemoglobins and red platelets. It has been a nightmare to say the least. I have received 5 doses of Doxil but will be switching to a new regiment as my CT revealed the two existing lesions have slightly grown. No other new growths noted!!!

I will now be on a dose reduction and a kidney friendly type chemo. I am looking for any advice on kidney friendly chemo drugs and a boost of confidence as I feel like no matter how hard I try these past 5 months I keep getting kicked!!!!

How many lines of treatment have we all been on???? Anybody with kidney issues???

I am thankful for any info you can provide.

Kind regards,

Nancy

[Lyndy]

Hello

I didn't have such a bad time on Avastin but at one stage my GP gave me a lecture about the fact that, although it wasn't big chemo, it was still a very powerful drug....so I am not surprised that it can cause problems like the ones you describe.

I'm interested that you still have high BP- had hoped mine would drop now I've finished Avastin. Hope you find kidney friendly chemo xx

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I haven't been on Avastin but I do have kidney issues. I have 2 kidney stents, that seem to be doing what they are supposed to do but I do get a few water infections, currently I'm on weekly taxol apparently it's kinder to my kidneys, I'm coping ok with it so far although get very tired. I am in kidney failure so whatever chemo they give me they have to make sure my kidney function is in the right parameters, I drink lots and lots and lots of water to help with this. this will be my 4th line, so no wonder my kidneys aren't great!

Wishing you all the best

Karen

Xx